%PDF-1.7
%
1 0 obj
<<
/PageMode /UseOutlines
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/Pages 5 0 R
/PageLayout /SinglePage
/OpenAction [6 0 R /FitH 810]
/Threads [7 0 R]
/StructTreeRoot 8 0 R
/Type /Catalog
/PageLabels 9 0 R
>>
endobj
10 0 obj
<<
/CrossMarkDomains#5B2#5D (elsevier.com)
/CrossmarkMajorVersionDate (2010-04-23)
/CreationDate (D:20180507184554+05'30')
/Subject (Molecular Metabolism, 11 \(2018\) 1-17. doi:10.1016/j.molmet.2018.02.013)
/Author (Yingfeng Deng)
/Creator (Elsevier)
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/ElsevierWebPDFSpecifications (6.5)
/CrossmarkDomainExclusive (true)
/robots (noindex)
/ModDate (D:20180507184647+05'30')
/doi (10.1016/j.molmet.2018.02.013)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/Title (Adipocyte Xbp1s overexpression drives uridine production and reduces obesity)
>>
endobj
2 0 obj
<<
/Dests 11 0 R
>>
endobj
3 0 obj
<<
/First 12 0 R
/Count 29
/Last 12 0 R
>>
endobj
4 0 obj
<<
/Subtype /XML
/Length 7906
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.molmet.2018.02.013
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity
Yingfeng Deng
Zhao V. Wang
Ruth Gordillo
Yi Zhu
Aktar Ali
Chen Zhang
Xiaoding Wang
Mengle Shao
Zhuzhen Zhang
Puneeth Iyengar
Rana K. Gupta
Jay D. Horton
Joseph A. Hill
Philipp E. Scherer
Obesity
Xbp1
ER stress
UPR
Pyrimidine
Uridine
CAD
Molecular Metabolism, 11 (2018) 1-17. doi:10.1016/j.molmet.2018.02.013
Elsevier GmbH
journal
Molecular Metabolism
© 2018 The Authors. Published by Elsevier GmbH.
2212-8778
11
May 2018
1-17
1
17
10.1016/j.molmet.2018.02.013
https://doi.org/10.1016/j.molmet.2018.02.013
2010-04-23
true
10.1016/j.molmet.2018.02.013
elsevier.com
sciencedirect.com
VoR
6.5
10.1016/j.molmet.2018.02.013
noindex
2010-04-23
true
sciencedirect.com
elsevier.com
Elsevier
2018-05-07T18:45:54+05:30
2018-05-07T18:46:47+05:30
2018-05-07T18:46:47+05:30
True
Acrobat Distiller 8.1.0 (Windows)
uuid:4fa26a00-ec73-4ea9-a2cc-35b511501c2f
uuid:fdbafc63-c009-4728-b4c7-042fd9fe03db
http://creativecommons.org/licenses/by-nc-nd/4.0/
endstream
endobj
5 0 obj
<<
/Count 17
/Type /Pages
/Kids [13 0 R 14 0 R]
>>
endobj
6 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R
25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R
35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R
45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R
55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
/Parent 13 0 R
/B [65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R]
/Contents 71 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 72 0 R
/Type /Page
>>
endobj
7 0 obj
<<
/F 65 0 R
/I 73 0 R
>>
endobj
8 0 obj
<<
/K [74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R
84 0 R 85 0 R]
/ParentTree 86 0 R
/ParentTreeNextKey 13
/Type /StructTreeRoot
>>
endobj
9 0 obj
<<
/Nums [0 87 0 R]
>>
endobj
11 0 obj
<<
/Kids [88 0 R 89 0 R]
>>
endobj
12 0 obj
<<
/First 90 0 R
/Parent 3 0 R
/Dest
/Count 28
/Last 91 0 R
/Title
>>
endobj
13 0 obj
<<
/Parent 5 0 R
/Count 10
/Type /Pages
/Kids [6 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R]
>>
endobj
14 0 obj
<<
/Parent 5 0 R
/Count 7
/Type /Pages
/Kids [101 0 R 102 0 R 103 0 R 104 0 R 105 0 R 106 0 R 107 0 R]
>>
endobj
15 0 obj
<<
/Rect [42.52 604.063 42.52 605.877]
/Subtype /Link
/A 108 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
16 0 obj
<<
/Rect [100.006 606.727 103.578 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
17 0 obj
<<
/Rect [109.02 604.063 109.02 605.877]
/Subtype /Link
/A 109 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
18 0 obj
<<
/Rect [163.786 606.727 167.357 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
19 0 obj
<<
/Rect [172.8 604.063 172.8 605.877]
/Subtype /Link
/A 110 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
20 0 obj
<<
/Rect [224.674 606.727 228.246 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
21 0 obj
<<
/Rect [233.688 604.063 233.688 605.877]
/Subtype /Link
/A 111 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
22 0 obj
<<
/Rect [259.427 606.727 262.998 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
23 0 obj
<<
/Rect [268.441 604.063 268.441 605.877]
/Subtype /Link
/A 112 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
24 0 obj
<<
/Rect [303.477 606.727 307.049 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
25 0 obj
<<
/Rect [312.491 604.063 312.491 605.877]
/Subtype /Link
/A 113 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
26 0 obj
<<
/Rect [359.49 606.727 363.061 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
27 0 obj
<<
/Rect [368.504 604.063 368.504 605.877]
/Subtype /Link
/A 114 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
28 0 obj
<<
/Rect [427.748 606.727 431.32 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
29 0 obj
<<
/Rect [433.644 606.727 437.216 615.685]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
30 0 obj
<<
/Rect [42.52 593.121 42.52 594.879]
/Subtype /Link
/A 115 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
31 0 obj
<<
/Rect [93.997 595.729 97.568 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
32 0 obj
<<
/Rect [103.011 593.121 103.011 594.879]
/Subtype /Link
/A 116 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
33 0 obj
<<
/Rect [163.105 595.729 166.677 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
34 0 obj
<<
/Rect [172.12 593.121 172.12 594.879]
/Subtype /Link
/A 117 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
35 0 obj
<<
/Rect [236.296 595.729 239.924 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
36 0 obj
<<
/Rect [245.31 593.121 245.31 594.879]
/Subtype /Link
/A 118 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
37 0 obj
<<
/Rect [302.23 595.729 305.801 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
38 0 obj
<<
/Rect [311.244 593.121 311.244 594.879]
/Subtype /Link
/A 119 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
39 0 obj
<<
/Rect [365.612 595.729 369.241 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
40 0 obj
<<
/Rect [374.683 593.121 374.683 594.879]
/Subtype /Link
/A 120 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
41 0 obj
<<
/Rect [429.619 595.729 433.19 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
42 0 obj
<<
/Rect [435.515 595.729 439.086 604.743]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
43 0 obj
<<
/Rect [42.52 582.179 42.52 583.937]
/Subtype /Link
/A 121 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
44 0 obj
<<
/Rect [113.046 584.787 116.617 593.745]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
45 0 obj
<<
/Rect [118.885 584.787 122.513 593.745]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
46 0 obj
<<
/Rect [124.781 584.787 128.296 593.745]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
47 0 obj
<<
/Rect [413.745 439.937 529.682 445.89]
/Subtype /Link
/A 122 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
48 0 obj
<<
/Rect [235.956 369.184 245.083 378.142]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
49 0 obj
<<
/Rect [66.784 314.419 75.912 323.376]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
50 0 obj
<<
/Rect [142.186 303.42 151.313 312.435]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
51 0 obj
<<
/Rect [92.523 281.537 101.65 290.494]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
52 0 obj
<<
/Rect [253.814 248.655 262.942 257.613]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
53 0 obj
<<
/Rect [230.343 171.95 239.357 180.907]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
54 0 obj
<<
/Rect [349.058 380.183 358.129 389.14]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
55 0 obj
<<
/Rect [484.554 358.242 493.625 367.2]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
56 0 obj
<<
/Rect [474.69 347.301 483.704 356.258]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
57 0 obj
<<
/Rect [293.556 314.419 302.627 323.376]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
58 0 obj
<<
/Rect [293.556 303.42 302.627 312.435]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
59 0 obj
<<
/Rect [451.446 248.655 464.938 257.613]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
60 0 obj
<<
/Rect [118.205 79.654 223.653 87.137]
/Subtype /Link
/A 123 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
61 0 obj
<<
/Rect [42.52 48.529 174.898 56.013]
/Subtype /Link
/A 124 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
62 0 obj
<<
/Rect [467.886 662.003 491.868 685.984]
/Subtype /Link
/A 125 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
63 0 obj
<<
/Rect [386.192 19.729 490.961 25.228]
/Subtype /Link
/A 126 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
64 0 obj
<<
/Rect [42.52 13.776 108.737 19.219]
/Subtype /Link
/A 127 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
65 0 obj
<<
/N 66 0 R
/P 6 0 R
/R [40 713 284 718]
/T 7 0 R
/V 128 0 R
>>
endobj
66 0 obj
<<
/N 67 0 R
/P 6 0 R
/R [40 639 462 693]
/T 7 0 R
/V 65 0 R
>>
endobj
67 0 obj
<<
/N 68 0 R
/P 6 0 R
/R [40 577 462 616]
/T 7 0 R
/V 66 0 R
>>
endobj
68 0 obj
<<
/N 69 0 R
/P 6 0 R
/R [40 415 536 569]
/T 7 0 R
/V 67 0 R
>>
endobj
69 0 obj
<<
/N 70 0 R
/P 6 0 R
/R [40 158 284 404]
/T 7 0 R
/V 68 0 R
>>
endobj
70 0 obj
<<
/N 129 0 R
/P 6 0 R
/R [291 158 536 404]
/T 7 0 R
/V 69 0 R
>>
endobj
71 0 obj
[130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R]
endobj
72 0 obj
<<
/XObject 139 0 R
/ColorSpace 140 0 R
/Font 141 0 R
/ProcSet [/PDF /Text /ImageC /ImageI]
/Properties 142 0 R
/ExtGState 143 0 R
>>
endobj
73 0 obj
<<
/Title
>>
endobj
74 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 1)
/Pg 93 0 R
/Alt (Image of Figure 1)
>>
endobj
75 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 2)
/Pg 94 0 R
/Alt (Image of Figure 2)
>>
endobj
76 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 3)
/Pg 95 0 R
/Alt (Image of Figure 3)
>>
endobj
77 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 3)
/Pg 96 0 R
/Alt (Image of Figure 3)
>>
endobj
78 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 4)
/Pg 98 0 R
/Alt (Image of Figure 4)
>>
endobj
79 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 4)
/Pg 99 0 R
/Alt (Image of Figure 4)
>>
endobj
80 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 5)
/Pg 100 0 R
/Alt (Image of Figure 5)
>>
endobj
81 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 5)
/Pg 101 0 R
/Alt (Image of Figure 5)
>>
endobj
82 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 6)
/Pg 102 0 R
/Alt (Image of Figure 6)
>>
endobj
83 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 6)
/Pg 103 0 R
/Alt (Image of Figure 6)
>>
endobj
84 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 7)
/Pg 104 0 R
/Alt (Image of Figure 7)
>>
endobj
85 0 obj
<<
/A 144 0 R
/K 0
/P 8 0 R
/S /Figure
/T (Figure 7)
/Pg 105 0 R
/Alt (Image of Figure 7)
>>
endobj
86 0 obj
<<
/Nums [1 [74 0 R]
2 [75 0 R]
3 [76 0 R]
4 [77 0 R]
5 [78 0 R]
6 [79 0 R]
7 [80 0 R]
8 [81 0 R]
9 [82 0 R]
10 [83 0 R]
11 [84 0 R]
12 [85 0 R]
]
>>
endobj
87 0 obj
<<
/St 1
/S /D
>>
endobj
88 0 obj
<<
/Limits [ ]
/Names [ 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R
150 0 R 151 0 R 152 0 R 153 0 R 154 0 R
155 0 R 156 0 R 157 0 R 158 0 R 159 0 R
160 0 R 161 0 R 162 0 R 163 0 R 164 0 R
165 0 R 166 0 R 167 0 R 168 0 R 169 0 R
170 0 R 171 0 R 172 0 R 173 0 R 174 0 R
175 0 R 176 0 R 177 0 R 178 0 R 179 0 R
180 0 R 181 0 R 182 0 R 183 0 R 184 0 R
185 0 R 186 0 R 187 0 R 188 0 R 189 0 R
190 0 R 191 0 R 192 0 R 193 0 R 194 0 R
195 0 R 196 0 R 197 0 R 198 0 R 199 0 R
200 0 R 201 0 R 202 0 R 203 0 R 204 0 R
205 0 R 206 0 R 207 0 R 208 0 R]
>>
endobj
89 0 obj
<<
/Limits [ ]
/Names [ 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R
214 0 R 215 0 R 216 0 R 217 0 R 218 0 R
219 0 R 220 0 R 221 0 R 222 0 R 223 0 R
224 0 R 225 0 R 226 0 R 227 0 R 228 0 R
229 0 R 230 0 R 231 0 R 232 0 R 233 0 R
234 0 R 235 0 R 236 0 R 237 0 R 238 0 R
239 0 R 240 0 R 241 0 R 242 0 R 243 0 R
244 0 R 245 0 R 246 0 R 247 0 R 248 0 R
249 0 R 250 0 R 251 0 R 252 0 R 253 0 R
254 0 R 255 0 R 256 0 R 257 0 R 258 0 R]
>>
endobj
90 0 obj
<<
/Parent 12 0 R
/Next 259 0 R
/Dest
/Title
>>
endobj
91 0 obj
<<
/Parent 12 0 R
/Dest
/Prev 260 0 R
/Title
>>
endobj
92 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R 270 0 R
271 0 R 272 0 R 273 0 R 274 0 R 275 0 R]
/Parent 13 0 R
/B [129 0 R 276 0 R]
/Contents 277 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 278 0 R
/Type /Page
>>
endobj
93 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R]
/Parent 13 0 R
/B [286 0 R 287 0 R]
/StructParents 1
/Contents 288 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 289 0 R
/Type /Page
>>
endobj
94 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R]
/Parent 13 0 R
/B [297 0 R 298 0 R]
/StructParents 2
/Contents 299 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 300 0 R
/Type /Page
>>
endobj
95 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R
311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R]
/Parent 13 0 R
/B [318 0 R 319 0 R]
/StructParents 3
/Contents 320 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 321 0 R
/Type /Page
>>
endobj
96 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R 328 0 R 329 0 R 330 0 R 331 0 R
332 0 R 333 0 R 334 0 R 335 0 R]
/Parent 13 0 R
/B [336 0 R 337 0 R]
/StructParents 4
/Contents 338 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 339 0 R
/Type /Page
>>
endobj
97 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R 348 0 R 349 0 R
350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R 358 0 R 359 0 R
360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R]
/Parent 13 0 R
/B [370 0 R 371 0 R]
/Contents 372 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 373 0 R
/Type /Page
>>
endobj
98 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [374 0 R 375 0 R]
/Parent 13 0 R
/StructParents 5
/Contents 376 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 377 0 R
/Type /Page
>>
endobj
99 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R
388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R]
/Parent 13 0 R
/B [395 0 R 396 0 R]
/StructParents 6
/Contents 397 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 398 0 R
/Type /Page
>>
endobj
100 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [399 0 R 400 0 R 401 0 R]
/Parent 13 0 R
/StructParents 7
/Contents 402 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 403 0 R
/Type /Page
>>
endobj
101 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [404 0 R 405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R
414 0 R 415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R]
/Parent 14 0 R
/B [422 0 R 423 0 R]
/StructParents 8
/Contents 424 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 425 0 R
/Type /Page
>>
endobj
102 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [426 0 R 427 0 R]
/Parent 14 0 R
/StructParents 9
/Contents 428 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 429 0 R
/Type /Page
>>
endobj
103 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [430 0 R 431 0 R 432 0 R 433 0 R 434 0 R 435 0 R]
/Parent 14 0 R
/B [436 0 R 437 0 R]
/StructParents 10
/Contents 438 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 439 0 R
/Type /Page
>>
endobj
104 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [440 0 R 441 0 R 442 0 R 443 0 R 444 0 R 445 0 R]
/Parent 14 0 R
/B [446 0 R 447 0 R]
/StructParents 11
/Contents 448 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 449 0 R
/Type /Page
>>
endobj
105 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [450 0 R 451 0 R 452 0 R 453 0 R]
/Parent 14 0 R
/B [454 0 R 455 0 R]
/StructParents 12
/Contents 456 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 457 0 R
/Type /Page
>>
endobj
106 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R 465 0 R 466 0 R 467 0 R
468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R 475 0 R 476 0 R 477 0 R
478 0 R 479 0 R 480 0 R 481 0 R 482 0 R 483 0 R 484 0 R 485 0 R]
/Parent 14 0 R
/B [486 0 R 487 0 R]
/Contents 488 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 489 0 R
/Type /Page
>>
endobj
107 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [490 0 R 491 0 R 492 0 R 493 0 R 494 0 R 495 0 R 496 0 R 497 0 R 498 0 R 499 0 R
500 0 R 501 0 R 502 0 R 503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R
510 0 R 511 0 R 512 0 R 513 0 R 514 0 R 515 0 R 516 0 R 517 0 R 518 0 R 519 0 R
520 0 R 521 0 R 522 0 R 523 0 R 524 0 R 525 0 R 526 0 R 527 0 R 528 0 R 529 0 R
530 0 R 531 0 R 532 0 R 533 0 R 534 0 R 535 0 R 536 0 R 537 0 R 538 0 R 539 0 R
540 0 R 541 0 R 542 0 R 543 0 R 544 0 R 545 0 R 546 0 R 547 0 R 548 0 R 549 0 R
550 0 R 551 0 R 552 0 R 553 0 R 554 0 R 555 0 R 556 0 R 557 0 R 558 0 R 559 0 R
560 0 R 561 0 R 562 0 R 563 0 R 564 0 R 565 0 R 566 0 R 567 0 R 568 0 R 569 0 R
570 0 R 571 0 R 572 0 R 573 0 R 574 0 R 575 0 R 576 0 R 577 0 R 578 0 R 579 0 R
580 0 R 581 0 R 582 0 R 583 0 R 584 0 R 585 0 R 586 0 R 587 0 R 588 0 R 589 0 R
590 0 R 591 0 R 592 0 R 593 0 R 594 0 R 595 0 R 596 0 R 597 0 R 598 0 R 599 0 R
600 0 R 601 0 R 602 0 R 603 0 R 604 0 R 605 0 R 606 0 R 607 0 R 608 0 R 609 0 R
610 0 R 611 0 R 612 0 R 613 0 R]
/Parent 14 0 R
/B [614 0 R 128 0 R]
/Contents 615 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 616 0 R
/Type /Page
>>
endobj
108 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
109 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
110 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
111 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
112 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
113 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
114 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
115 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
116 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
117 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
118 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
119 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
120 0 obj
<<
/URI (Delta:1_given name)
/S /URI
>>
endobj
121 0 obj
<<
/URI (Delta:1_surname)
/S /URI
>>
endobj
122 0 obj
<<
/URI (http://creativecommons.org/licenses/by-nc-nd/4.0/)
/S /URI
>>
endobj
123 0 obj
<<
/URI (mailto:Philipp.Scherer@utsouthwestern.edu)
/S /URI
>>
endobj
124 0 obj
<<
/URI (https://doi.org/10.1016/j.molmet.2018.02.013)
/S /URI
>>
endobj
125 0 obj
<<
/URI (http://crossmark.crossref.org/dialog/?doi=10.1016/j.molmet.2018.02.013&domain=pdf)
/S /URI
>>
endobj
126 0 obj
<<
/URI (http://creativecommons.org/licenses/by-nc-nd/4.0/)
/S /URI
>>
endobj
127 0 obj
<<
/URI (http://www.molecularmetabolism.com)
/S /URI
>>
endobj
128 0 obj
<<
/N 65 0 R
/P 107 0 R
/R [291 197 536 718]
/T 7 0 R
/V 614 0 R
>>
endobj
129 0 obj
<<
/N 276 0 R
/P 92 0 R
/R [60 42 304 716]
/T 7 0 R
/V 70 0 R
>>
endobj
130 0 obj
<<
/Length 1954
/Filter /FlateDecode
>>
stream
HWvF=Wp10;YJI&cg$pM(R#-uVrr\_ANd~w?DY=1[DIY&ͅ'.%.WyU.m6ie-*ЇKV:ZYt~]O:YW|M3ɕd~
U]eOgGO=:ÉXEKV&