Touchstone Diabetes Center

Researchers find shape-shifting fat cells can fuel breast cancer growth

In this episode of Science Café, Dr. Gupta discusses the problem of obesity and the enigma of why the expansion of fat tissue can lead to diabetes and metabolic syndrome in some individuals but not others. He also highlights how “fixing our fat” can break the link between obesity and diabetes or even protect against obesity itself. Learn how fat tissue is not our foe, but rather our friend. Dr. Gupta is an Associate Professor of Internal Medicine at UT Southwestern Medical Center, and joined the Touchstone Diabetes Center in 2012.

Factors inherent to obesity could increase vulnerability to COVID-19

Inflammation in the lungs combined with high viral loads of the novel coronavirus create a perfect storm for obese patients with COVID-19, UTSW scientists say

UTSW Study Links Alzheimer's-Related Protein To Diabetes And Obesity

A new study found a protein linked to Alzheimer’s Disease also contributes to problems with diabetes and obesity.

It’s called the amyloid precursor protein or APP. That’s the same amyloid believed to form plaque that may cause cognitive decline. The study, published in Nature Metabolism, found APP occurs in far higher levels in the fat cells of mice and humans who are obese. Follow the link to read more

www.keranews.org

"Plugged In To DFW 3: Obesity And Children"

Dr. Olga Gupta of UTSouthwestern Medical Center talks about Texas having the seventh highest obesity rate for youth ages 10 to 17.

UTSouthwestern Newsroom
“Study suggests antibody might be a new tool to fight obesity”

Dr. Philipp Scherer wins “Triple Crown” of Diabetes research awards.

UTSW Article
Molmet YFDeng

Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang,
Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill,
Philipp E. Scherer

Adipocyte Xbp1s overexpression drives
uridine production and reduces obesity

Publication
MitoNEET CKusminski

Christine M Kusminski, William L Holland, Kai Sun, Jiyoung Park, Stephen B Spurgin, Ying Lin,
G Roger Askew, Judith A Simcox, Don A McClain, Cai Li & Philipp E Scherer

MitoNEET-driven alterations in
adipocyte mitochondrial activity
reveal a crucial adaptive process
that preserves insulin sensitivity
in obesity

Publication
HollandCover

William L. Holland, Jonathan Y. Xia, Joshua A. Johnson, Kai Sun, Mackenzie J. Pearson,
Ankit X. Sharma, Ezekiel Quittner-Strom, Trevor S. Tippetts, Ruth Gordillo, Philipp E. Scherer,

Inducible overexpression of adiponectin
receptors highlight the roles of
adiponectin-induced ceramidase signaling
in lipid and glucose homeostasis

Publication
ckusmi molmet

Christine M. Kusminski 1, Violeta I. Gallardo-Montejano 2, Zhao V. Wang 1, Vijay Hegde 3,5, Perry E. Bickel 2,
Nikhil V. Dhurandhar 3,5,**, Philipp E. Scherer 1,4,*

Christine M. Kusminski, Violeta I. Gallardo-Montejano, Zhao V. Wang, Vijay Hegde, Perry E. Bickel, Nikhil V. Dhurandhar,
Philipp E. Scherer

E4orf1 induction in adipose tissue promotes
insulin-independent signaling in the adipocyte

E4orf1 induction in adipose tissue
promotes insulin-independent
signaling in the adipocyte

Publication
CirculationResearch PScherer

Philipp E. Scherer, Joseph A. Hill

Obesity, Diabetes, and Cardiovascular
DiseasesA Compendium

Publication
PER Ja-young kim

Ja-Young Kim and Philipp E. Scherer, Ph.D.

Adiponectin, an Adipocyte-Derived Hepatic Insulin Sensitizer
Regulation During Development

Publication
ACRP30 Structure

Lawrence Shapiro and Philipp E. Scherer

The crystal structure of a complement-1q family protein suggests
an evolutionary link to tumor necrosis factor

Publication
Jcellbio Gender Differences

Jorge L. Durand, Andrea R. Nawrocki,
Philipp E. Scherer, and Linda A. Jelicks

Gender Differences in Adiponectin Modulation of Cardiac Remodeling
in Mice Deficient in Endothelial
Nitric Oxide Synthase

Publication
Cell Met Ingrid

Ingrid Wernstedt Asterholm, Dorothy Mundy, Jian Weng, Richard G.W. Anderson,
and Philipp E. Scherer

Altered Mitochondrial Functionand Metabolic Inflexibility Associated with Loss of Caveolin-1

Publication
Cab45

Philipp E. Seherer, Gerardo Z. Lederkremer, Suzanne WiUiams, Michael Fogliano, Giulia Baldini,
and Harvey F. Lodish

Cab45, a Novel Ca2+-binding Protein Localized to the Golgi Lumen

Publication
Cell Met Ingrid - copy

Roger H. Unger1, and Philipp E. Scherer

Gluttony, sloth and the metabolic
syndrome: a roadmap to lipotoxicity

Publication
EMBO Scherer

Philipp E.Scherer, Ute C.Krieg,
Sam T.Hwang . Dietmar Vestweber .
and Gottfried Schatz

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein

Publication
CombsEndo

TERRY P. COMBS, et al

A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity

A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity

Publication
MCB Khan

Tayeba Khan,1 Eric S. Muise,2 Puneeth Iyengar,1‡ Zhao V. Wang,3 Manisha Chandalia,4 Nicola Abate,4 Bei B. Zhang,5 Paolo Bonaldo,6 Streamson Chua,7 and Philipp E. Scherer3,8

Tayeba Khan, Eric S. Muise, Puneeth Iyengar, Zhao V. Wang, Manisha Chandalia,
Nicola Abate, Bei B. Zhang, Paolo Bonaldo,
Streamson Chua, and Philipp E. Scherer

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of
Collagen VI†

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†

Publication
MCB Khan - copy

Qiong A. Wang,a,b Fang Zhang,a,d Lei Jiang,b Risheng Ye,a Yu An,a Mengle Shao,a Caroline Tao,a Rana K. Gupta,a
Philipp E. Scherera,c

Qiong A. Wang, Fang Zhang, Lei Jiang, Risheng Ye,a Yu An, Mengle Shao, Caroline Tao, Rana K. Gupta,
Philipp E. Scherera,

Publication

Peroxisome Proliferator-Activated Receptor  and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated
Insulin Sensitization

Peroxisome Proliferator-Activated Receptor
and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Kruglikov Trends in endo

Ilja L. Kruglikov and Philipp E. Scherer

Dermal Adipocytes : From Irrelevance
to Metabolic Targets?

Publication
Ye Molmet

Risheng Ye, Miao Wang, Qiong A. Wang, Stephen B. Spurgin, Zhao V. Wang, Kai Sun,
Philipp E. Scherer

Autonomous interconversion between
adult pancreatic a-cells and b-cells after differential metabolic challenges

Publication
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Philipp E. Scherer, PhD

Philipp E. Scherer, PhD

Professor and Director

Adipose tissue physiology and pathophysiology and its impact on systemic energy homeostasis in diabetes, obesity, cardiovascular disease and cancer.

Visit the Scherer Lab

Olga Gupta M.D.

Olga Gupta M.D.

Assistant Professor

Pediatric diabetes care; Psychosocial mechanisms leading to poor adherence to diabetes self-management tasks in young individuals with type 1 diabetes; Molecular aspects of visceral adipose tissue mesothelial cells
Visit the O. Gutpa Lab

Christine Kusminski Ph.D.

Christine Kusminski Ph.D.

Assistant Professor

Mitochondrial bioenergetics in the context of adipose tissue physiology and energy metabolism. Evaluation of the integrated signaling mechanisms that govern white adipose tissue expansion.
Roger Unger M.D.

Roger Unger M.D.

Professor

Adipose tissue physiology, beta and alpha cell crosstalk, the role of glucagon in normal and pathophysiological states and the impact of these hormones on carbohydrate and lipid metabolism.

Visit the Unger Lab

Dayoung Oh Ph.D.

Dayoung Oh Ph.D.

Assistant Professor

Studying the role of GPCRs in obesity, inflammation and Type 2 Diabetes.

 

Visit the Oh Lab

Yingfeng Deng, Ph.D.

Yingfeng Deng, Ph.D.

Assistant Professor

.Systemic relevance of the uridine biosynthetic pathway in the fasting and fed states.
Rana Gupta, Ph.D.

Rana Gupta, Ph.D.

Associate Professor

Adipocyte development, adipose tissue physiology, transcriptional regulation, pathogenesis of type 2 diabetes

 

Visit the R. Gupta Lab

Ruth Gordillo, Ph.D.

Ruth Gordillo, Ph.D.

Associate Professor

Specializing  in the development of LC/MS/MS technologies for the determination and quantification of metabolites.

Visit the Metabolic Core

Jaime A. Davidson, M.D., F.A.C.P., F.A.C.E.

Jaime A. Davidson, M.D., F.A.C.P., F.A.C.E.

Emeritus Professor

Clinical aspects of diabetes and its treatment with novel pharmacological agents.

Visit Jaime Davidson’s page

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