Touchstone Diabetes Center

William L. Holland 1,*,4, Jonathan Y. Xia 1,4, Joshua A. Johnson 1, Kai Sun 2, Mackenzie J. Pearson 1,
Ankit X. Sharma 1, Ezekiel Quittner-Strom 1, Trevor S. Tippetts 1, Ruth Gordillo 1, Philipp E. Scherer 1,3

Inducible overexpression of adiponectin
receptors highlight the roles of
adiponectin-induced ceramidase signaling
in lipid and glucose homeostasis

Ja-Young Kim1 and Philipp E. Scherer, PhD1,2,3

Adiponectin, an Adipocyte-Derived Hepatic Insulin Sensitizer
Regulation During Development

Yingfeng Deng et al.

Adipocyte Xbp1s Drives
Uridine Production

Lawrence Shapiro* and Philipp E. Scherer

The crystal structure of a complement-1q family protein suggests
an evolutionary link to tumor necrosis factor

Jorge L. Durand,1 Andrea R. Nawrocki,2
Philipp E. Scherer,2,3 and Linda A. Jelicks1,4*

Gender Differences in Adiponectin Modulation of Cardiac Remodeling
in Mice Deficient in Endothelial
Nitric Oxide Synthase

Philipp E. Seherer,* Gerardo Z. Lederkremer,* Suzanne WiUiams, ~ Michael Fogliano, § Giulia Baldini,*
and Harvey F. Lodish*

Cab45, a Novel Ca2+-binding Protein Localized to the Golgi Lumen

Christine M Kusminski1, William L Holland1, Kai Sun1, Jiyoung Park1, Stephen B Spurgin1, Ying Lin2,
G Roger Askew3, Judith A Simcox4, Don A McClain4,5, Cai Li3 & Philipp E Scherer1,6

MitoNEET-driven alterations in
adipocyte mitochondrial activity
reveal a crucial adaptive process
that preserves insulin sensitivity
in obesity

Philipp E. Scherer, Joseph A. Hill

Obesity, Diabetes, and Cardiovascular
DiseasesA Compendium

Yingfeng Deng 1, Zhao V. Wang 2, Ruth Gordillo 1, Yi Zhu 1, Aktar Ali 1, Chen Zhang 1, Xiaoding Wang 2,7,
Mengle Shao 1, Zhuzhen Zhang 1, Puneeth Iyengar 3, Rana K. Gupta 1, Jay D. Horton 4, Joseph A. Hill 2,5,
Philipp E. Scherer 1,6,*

Adipocyte Xbp1s overexpression drives
uridine production and reduces obesity

Ingrid Wernstedt Asterholm,1 Dorothy I. Mundy,1,2 Jian Weng,2 Richard G.W. Anderson,2,3 and Philipp E. Scherer1,2,*

Altered Mitochondrial Functionand Metabolic Inflexibility Associated with Loss of Caveolin-1

Roger H. Unger1,2 and Philipp E. Scherer1

Gluttony, sloth and the metabolic
syndrome: a roadmap to lipotoxicity

Philipp E.Scherer, Ute C.Krieg,
Sam T.Hwang1 . Dietmar Vestweber2 .
and Gottfried Schatz

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein

TERRY P. COMBS, et al

A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity

A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity

Christine M. Kusminski 1, Violeta I. Gallardo-Montejano 2, Zhao V. Wang 1, Vijay Hegde 3,5, Perry E. Bickel 2,
Nikhil V. Dhurandhar 3,5,**, Philipp E. Scherer 1,4,*

Christine M. Kusminski 1, Violeta I. Gallardo-Montejano 2, Zhao V. Wang 1, Vijay Hegde 3,5, Perry E. Bickel 2,
Nikhil V. Dhurandhar 3,5,**, Philipp E. Scherer 1,4,*

E4orf1 induction in adipose tissue promotes
insulin-independent signaling in the adipocyte

E4orf1 induction in adipose tissue
promotes insulin-independent
signaling in the adipocyte

Tayeba Khan,1 Eric S. Muise,2 Puneeth Iyengar,1‡ Zhao V. Wang,3 Manisha Chandalia,4 Nicola Abate,4 Bei B. Zhang,5 Paolo Bonaldo,6 Streamson Chua,7 and Philipp E. Scherer3,8

Tayeba Khan,1 Eric S. Muise,2 Puneeth Iyengar,1‡ Zhao V. Wang,3 Manisha Chandalia,4
Nicola Abate,4 Bei B. Zhang,5 Paolo Bonaldo,6
Streamson Chua,7 and Philipp E. Scherer3,8

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of
Collagen VI†

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†

Qiong A. Wang,a,b Fang Zhang,a,d Lei Jiang,b Risheng Ye,a Yu An,a Mengle Shao,a Caroline Tao,a Rana K. Gupta,a
Philipp E. Scherera,c

Qiong A. Wang,a,b Fang Zhang,a,d Lei Jiang,b Risheng Ye,a Yu An,a Mengle Shao,a Caroline Tao,a Rana K. Gupta,a
Philipp E. Scherera,c

Peroxisome Proliferator-Activated Receptor  and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated
Insulin Sensitization

Peroxisome Proliferator-Activated Receptor
and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Ilja L. Kruglikov1 and Philipp E. Scherer2,*

Dermal Adipocytes : From Irrelevance
to Metabolic Targets?

Risheng Ye 1, Miao Wang 2, Qiong A. Wang 1, Stephen B. Spurgin 1, Zhao V. Wang 1, Kai Sun 1,4,
Philipp E. Scherer 1,3,*

Autonomous interconversion between
adult pancreatic a-cells and b-cells after differential metabolic challenges

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Philipp E. Scherer, PhD

Philipp E. Scherer, PhD

Professor and Director

Adipose tissue physiology and pathophysiology and its impact on systemic energy homeostasis in diabetes, obesity, cardiovascular disease and cancer.
Olga Gupta M.D.

Olga Gupta M.D.

Assistant Professor

 
Christine Kusminski Ph.D.

Christine Kusminski Ph.D.

Assistant Professor

Mitochondrial bioenergetics in the context of adipose tissue physiology and energy metabolism. Evaluation of the integrated signaling mechanisms that govern white adipose tissue expansion.
Roger Unger M.D.

Roger Unger M.D.

Professor

Adipose tissue physiology, beta and alpha cell crosstalk, the role of glucagon in normal and pathophysiological states and the impact of these hormones on carbohydrate and lipid metabolism.

Dayoung Oh Ph.D.

Dayoung Oh Ph.D.

Assistant Professor

Studying the role of GPCRs in obesity, inflammation and Type 2 Diabetes.
 
Yingfeng Deng, Ph.D.

Yingfeng Deng, Ph.D.

Assistant Professor

.Systemic relevance of the uridine biosynthetic pathway in the fasting and fed states.

Rana Gupta, Ph.D.

Rana Gupta, Ph.D.

Associate Professor

Adipocyte development, adipose tissue physiology, transcriptional regulation, pathogenesis of type 2 diabetes

Ruth Gordillo, Ph.D.

Ruth Gordillo, Ph.D.

Assistant Professor

Specializing  in the development of LC/MS/MS technologies for the determination and quantification of metabolites.
Jaime A. Davidson, M.D., F.A.C.P., F.A.C.E.

Jaime A. Davidson, M.D., F.A.C.P., F.A.C.E.

Emeritus Professor

Clinical aspects of diabetes and its treatment with novel pharmacological agents.