Touchstone Diabetes Center

Find out how adipose progenitors respond to metabolic states: two fascinating papers (Jofﬁn and Shao) @CellStemCell reveal how adipose-tissue-resident PDGFRb+precursor cell fate is regulated by mitochondrial bio- energetics and how such processes go wrong in obesity pic.twitter.com/1pw35usUfL
— Cell Biology UTSW (@CellUtsw) April 5, 2021

Factors inherent to obesity could increase vulnerability to COVID-19

Inflammation in the lungs combined with high viral loads of the novel coronavirus create a perfect storm for obese patients with COVID-19, UTSW scientists say

UTSW Study Links Alzheimer's-Related Protein To Diabetes And Obesity

A new study found a protein linked to Alzheimer’s Disease also contributes to problems with diabetes and obesity.

It’s called the amyloid precursor protein or APP. That’s the same amyloid believed to form plaque that may cause cognitive decline. The study, published in Nature Metabolism, found APP occurs in far higher levels in the fat cells of mice and humans who are obese. Follow the link to read more

www.keranews.org

"Plugged In To DFW 3: Obesity And Children"

Dr. Olga Gupta of UTSouthwestern Medical Center talks about Texas having the seventh highest obesity rate for youth ages 10 to 17.

UTSouthwestern Newsroom
“Study suggests antibody might be a new tool to fight obesity”

Dr. Philipp Scherer wins “Triple Crown” of Diabetes research awards.

UTSW Article

Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang,
Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill,
Philipp E. Scherer

Adipocyte Xbp1s overexpression drives
uridine production and reduces obesity

Publication

Christine M Kusminski, William L Holland, Kai Sun, Jiyoung Park, Stephen B Spurgin, Ying Lin,
G Roger Askew, Judith A Simcox, Don A McClain, Cai Li & Philipp E Scherer

MitoNEET-driven alterations in
adipocyte mitochondrial activity
reveal a crucial adaptive process
that preserves insulin sensitivity
in obesity

Publication

William L. Holland, Jonathan Y. Xia, Joshua A. Johnson, Kai Sun, Mackenzie J. Pearson,
Ankit X. Sharma, Ezekiel Quittner-Strom, Trevor S. Tippetts, Ruth Gordillo, Philipp E. Scherer,

Inducible overexpression of adiponectin
receptors highlight the roles of
adiponectin-induced ceramidase signaling
in lipid and glucose homeostasis

Publication

Christine M. Kusminski 1, Violeta I. Gallardo-Montejano 2, Zhao V. Wang 1, Vijay Hegde 3,5, Perry E. Bickel 2,
Nikhil V. Dhurandhar 3,5,**, Philipp E. Scherer 1,4,*

Christine M. Kusminski, Violeta I. Gallardo-Montejano, Zhao V. Wang, Vijay Hegde, Perry E. Bickel, Nikhil V. Dhurandhar,
Philipp E. Scherer

E4orf1 induction in adipose tissue promotes
insulin-independent signaling in the adipocyte

E4orf1 induction in adipose tissue
promotes insulin-independent
signaling in the adipocyte

Publication

Philipp E. Scherer, Joseph A. Hill

Obesity, Diabetes, and Cardiovascular
DiseasesA Compendium

Publication

Ja-Young Kim and Philipp E. Scherer, Ph.D.

Adiponectin, an Adipocyte-Derived Hepatic Insulin Sensitizer
Regulation During Development

Publication

Lawrence Shapiro and Philipp E. Scherer

The crystal structure of a complement-1q family protein suggests
an evolutionary link to tumor necrosis factor

Publication

Jorge L. Durand, Andrea R. Nawrocki,
Philipp E. Scherer, and Linda A. Jelicks

Gender Differences in Adiponectin Modulation of Cardiac Remodeling
in Mice Deficient in Endothelial
Nitric Oxide Synthase

Publication

Ingrid Wernstedt Asterholm, Dorothy Mundy, Jian Weng, Richard G.W. Anderson,
and Philipp E. Scherer

Altered Mitochondrial Functionand Metabolic Inflexibility Associated with Loss of Caveolin-1

Publication

Philipp E. Seherer, Gerardo Z. Lederkremer, Suzanne WiUiams, Michael Fogliano, Giulia Baldini,
and Harvey F. Lodish

Cab45, a Novel Ca2+-binding Protein Localized to the Golgi Lumen

Publication

Roger H. Unger1, and Philipp E. Scherer

Gluttony, sloth and the metabolic
syndrome: a roadmap to lipotoxicity

Publication

Philipp E.Scherer, Ute C.Krieg,
Sam T.Hwang . Dietmar Vestweber .
and Gottfried Schatz

A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein

Publication

TERRY P. COMBS, et al

A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity

Publication

Tayeba Khan,1 Eric S. Muise,2 Puneeth Iyengar,1‡ Zhao V. Wang,3 Manisha Chandalia,4 Nicola Abate,4 Bei B. Zhang,5 Paolo Bonaldo,6 Streamson Chua,7 and Philipp E. Scherer3,8

Tayeba Khan, Eric S. Muise, Puneeth Iyengar, Zhao V. Wang, Manisha Chandalia,
Nicola Abate, Bei B. Zhang, Paolo Bonaldo,
Streamson Chua, and Philipp E. Scherer

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of
Collagen VI†

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†

Publication

Qiong A. Wang,a,b Fang Zhang,a,d Lei Jiang,b Risheng Ye,a Yu An,a Mengle Shao,a Caroline Tao,a Rana K. Gupta,a
Philipp E. Scherera,c

Qiong A. Wang, Fang Zhang, Lei Jiang, Risheng Ye,a Yu An, Mengle Shao, Caroline Tao, Rana K. Gupta,
Philipp E. Scherera,

Publication

Peroxisome Proliferator-Activated Receptor and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated
Insulin Sensitization

Peroxisome Proliferator-Activated Receptor
and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Ilja L. Kruglikov and Philipp E. Scherer

Dermal Adipocytes : From Irrelevance
to Metabolic Targets?

Publication

Risheng Ye, Miao Wang, Qiong A. Wang, Stephen B. Spurgin, Zhao V. Wang, Kai Sun,
Philipp E. Scherer

Autonomous interconversion between
adult pancreatic a-cells and b-cells after differential metabolic challenges

Publication

Philipp E. Scherer, PhD

Professor and Director

Adipose tissue physiology and pathophysiology and its impact on systemic energy homeostasis in diabetes, obesity, cardiovascular disease and cancer.

Visit the Scherer Lab

Olga Gupta M.D.

Assistant Professor

Pediatric diabetes care; Psychosocial mechanisms leading to poor adherence to diabetes self-management tasks in young individuals with type 1 diabetes; Molecular aspects of visceral adipose tissue mesothelial cells
Visit the O. Gutpa Lab

Christine Kusminski Ph.D.

Assistant Professor

Mitochondrial bioenergetics in the context of adipose tissue physiology and energy metabolism. Evaluation of the integrated signaling mechanisms that govern white adipose tissue expansion.

Roger Unger M.D.

Professor

Adipose tissue physiology, beta and alpha cell crosstalk, the role of glucagon in normal and pathophysiological states and the impact of these hormones on carbohydrate and lipid metabolism.

Visit the Unger Lab