Touchstone Diabetes Center
UTSW Study Links Alzheimer's-Related Protein To Diabetes And Obesity
A new study found a protein linked to Alzheimer’s Disease also contributes to problems with diabetes and obesity.
It’s called the amyloid precursor protein or APP. That’s the same amyloid believed to form plaque that may cause cognitive decline. The study, published in Nature Metabolism, found APP occurs in far higher levels in the fat cells of mice and humans who are obese. Follow the link to read more
"Plugged In To DFW 3: Obesity And Children"
Dr. Olga Gupta of UTSouthwestern Medical Center talks about Texas having the seventh highest obesity rate for youth ages 10 to 17.
UTSouthwestern Newsroom
“Study suggests antibody might be a new tool to fight obesity”
Dr. Philipp Scherer wins “Triple Crown” of Diabetes research awards.
Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang,
Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill,
Philipp E. Scherer
Adipocyte Xbp1s overexpression drives
uridine production and reduces obesity
Christine M Kusminski, William L Holland, Kai Sun, Jiyoung Park, Stephen B Spurgin, Ying Lin,
G Roger Askew, Judith A Simcox, Don A McClain, Cai Li & Philipp E Scherer
MitoNEET-driven alterations in
adipocyte mitochondrial activity
reveal a crucial adaptive process
that preserves insulin sensitivity
in obesity
William L. Holland, Jonathan Y. Xia, Joshua A. Johnson, Kai Sun, Mackenzie J. Pearson,
Ankit X. Sharma, Ezekiel Quittner-Strom, Trevor S. Tippetts, Ruth Gordillo, Philipp E. Scherer,
Inducible overexpression of adiponectin
receptors highlight the roles of
adiponectin-induced ceramidase signaling
in lipid and glucose homeostasis
Christine M. Kusminski 1, Violeta I. Gallardo-Montejano 2, Zhao V. Wang 1, Vijay Hegde 3,5, Perry E. Bickel 2,
Nikhil V. Dhurandhar 3,5,**, Philipp E. Scherer 1,4,*
Christine M. Kusminski, Violeta I. Gallardo-Montejano, Zhao V. Wang, Vijay Hegde, Perry E. Bickel, Nikhil V. Dhurandhar,
Philipp E. Scherer
E4orf1 induction in adipose tissue promotes
insulin-independent signaling in the adipocyte
E4orf1 induction in adipose tissue
promotes insulin-independent
signaling in the adipocyte
Philipp E. Scherer, Joseph A. Hill
Obesity, Diabetes, and Cardiovascular
DiseasesA Compendium
Ja-Young Kim and Philipp E. Scherer, Ph.D.
Adiponectin, an Adipocyte-Derived Hepatic Insulin Sensitizer
Regulation During Development
Lawrence Shapiro and Philipp E. Scherer
The crystal structure of a complement-1q family protein suggests
an evolutionary link to tumor necrosis factor
Jorge L. Durand, Andrea R. Nawrocki,
Philipp E. Scherer, and Linda A. Jelicks
Gender Differences in Adiponectin Modulation of Cardiac Remodeling
in Mice Deficient in Endothelial
Nitric Oxide Synthase
Ingrid Wernstedt Asterholm, Dorothy Mundy, Jian Weng, Richard G.W. Anderson,
and Philipp E. Scherer
Altered Mitochondrial Functionand Metabolic Inflexibility Associated with Loss of Caveolin-1
Philipp E. Seherer, Gerardo Z. Lederkremer, Suzanne WiUiams, Michael Fogliano, Giulia Baldini,
and Harvey F. Lodish
Cab45, a Novel Ca2+-binding Protein Localized to the Golgi Lumen
Roger H. Unger1, and Philipp E. Scherer
Gluttony, sloth and the metabolic
syndrome: a roadmap to lipotoxicity
Philipp E.Scherer, Ute C.Krieg,
Sam T.Hwang . Dietmar Vestweber .
and Gottfried Schatz
A precursor protein partly translocated into yeast mitochondria is bound to a 70 kd mitochondrial stress protein
TERRY P. COMBS, et al
A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity
A Transgenic Mouse with a Deletion in the Collagenous
Domain of Adiponectin Displays Elevated Circulating
Adiponectin and Improved Insulin Sensitivity
Tayeba Khan,1 Eric S. Muise,2 Puneeth Iyengar,1‡ Zhao V. Wang,3 Manisha Chandalia,4 Nicola Abate,4 Bei B. Zhang,5 Paolo Bonaldo,6 Streamson Chua,7 and Philipp E. Scherer3,8
Tayeba Khan, Eric S. Muise, Puneeth Iyengar, Zhao V. Wang, Manisha Chandalia,
Nicola Abate, Bei B. Zhang, Paolo Bonaldo,
Streamson Chua, and Philipp E. Scherer
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of
Collagen VI†
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†
Qiong A. Wang,a,b Fang Zhang,a,d Lei Jiang,b Risheng Ye,a Yu An,a Mengle Shao,a Caroline Tao,a Rana K. Gupta,a
Philipp E. Scherera,c
Qiong A. Wang, Fang Zhang, Lei Jiang, Risheng Ye,a Yu An, Mengle Shao, Caroline Tao, Rana K. Gupta,
Philipp E. Scherera,
Peroxisome Proliferator-Activated Receptor and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated
Insulin Sensitization
Peroxisome Proliferator-Activated Receptor
and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization
Ilja L. Kruglikov and Philipp E. Scherer
Dermal Adipocytes : From Irrelevance
to Metabolic Targets?
Risheng Ye, Miao Wang, Qiong A. Wang, Stephen B. Spurgin, Zhao V. Wang, Kai Sun,
Philipp E. Scherer
Autonomous interconversion between
adult pancreatic a-cells and b-cells after differential metabolic challenges
Philipp E. Scherer, PhD
Professor and Director
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Olga Gupta M.D.
Assistant Professor
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Christine Kusminski Ph.D.
Assistant Professor
Roger Unger M.D.
Professor
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Dayoung Oh Ph.D.
Assistant Professor
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Yingfeng Deng, Ph.D.
Assistant Professor
Rana Gupta, Ph.D.
Associate Professor
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Ruth Gordillo, Ph.D.
Associate Professor
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Jaime A. Davidson, M.D., F.A.C.P., F.A.C.E.
Emeritus Professor
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