2017/2018 Publications               


Primary Papers, Reviews and Commentaries from the Lab in 2017-2018:


Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. 2018.

An Endothelial to Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.

Cell, 175(3):695-708




Kruglikov IL, Zhang Z, Scherer PE. 2018.

The Role of Immature and Mature Adipocytes in Hair Cycling

Trends Endocrinol Metab., in press


Scherer PE. 2018.

The many secret lives of adipocytes: implications for diabetes

Diabetologia, in press



Joffin N, Scherer PE. 2018.

Reducing oxygen consumption in fat

Nature, in press



Ghaben AL, Scherer PE. 2018.

Adipogenesis and Metabolic Health

Nature Reviews Molecular Cell Biology, in press


Kruglikov IL, Scherer PE. 2018.

Skin aging as a mechanical phenomenon: The main weak links.

Nutr Healthy Aging; 4(4):291-307



Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer P.E. 2018.

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors During Lactation.      

Cell Metabolism, 28(2):282-288



Kusminski CM, Scherer PE. 2018.

New zoning laws enforced by glucagon.

Proc Natl Acad Sci U S A., 115(17):4308-4310



Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar I, Gupta RK, Horton JD, Hill JA, Scherer PE. 2018.

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Molecular Metabolism, 11:1-17



Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. 2018.

Intracellular lipid metabolism impairs β-cell compensation during diet-induced obesity

  1. Clin. Inv., 128(3):1178-1189



Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. 2018.

PPARγ and its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Mol. Cell Biol., in press



Zhu Y, Kruglikov IL, Akgul Y, Scherer PE. 2018.

Hyaluronan in Adipogenesis, Adipose Tissue Physiology and Systemic Metabolism

Matrix Biology, in press



Zhang Z, Scherer PE. 2018.

The dysfunctional adipocyte — a cancer cell’s best friend

Nat Rev Endocrinol., 14(3):132-134



Zhu Q, Scherer PE. 2018.

Immunologic and endocrine functions of adipose tissue: implications for kidney disease.

Nat Rev Nephrol., 14(2):105-120



Zhang F, Hao G, Shao M, Hassan G, An YA, Wang Q, Zhu Y, Kusminski CM, Nham K, Gupta RK, Zhai Q, Sun X, Scherer PE*, Oz OK*. 2018.

An Adipose Tissue Atlas: An Image Guided Identification of Human-like BAT and Beige Depots in Rodents.

Cell Metabolism, 27(1):252-262.



Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. 2017.

Acute Loss of Adipose Tissue-Derived Adiponectin Triggers Immediate Metabolic Deterioration.

Diabetologia, 61(4):932-941



Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. 2017.

Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression.

Diabetes, 66(11):2789-2799



Kruglikov IL, Scherer PE. 2017.

General theory of skin reinforcement.

PLoS One. 12(8):e0182865



Kruglikov IL, Scherer PE. 2017.

Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.

Exp Dermatol. 26(6):522-523



An YA, Sun K, Joffin N, Zhang F, Deng Y, Donzé O, Kusminski CM, Scherer PE. 2017.

Angiopoietin-2 in White Adipose Tissue Improves Metabolic Homeostasis through Enhanced Angiogenesis.

eLife, e24071



Tao C, Holland WL, Wang QA, Shao M, Lin J, Sun K,  Lin X, Kuo Y-C, Johnson JA, Gordillo R, Elmquist, JK and P E Scherer. 2017.

Short-Term vs. Long-Term Effects of Adipocyte Toll-like Receptor 4 Activation on Insulin Resistance in Male Mice.

Endocrinology, 158(5):1260-1270



Park J*, Kim M*, Sun K*, An YA*, Gu X and P E Scherer. 2017.

VEGF-A expressing adipose tissue shows rapid beiging, enhanced survival after transplantation and confers IL4-independent metabolic improvements.

Diabetes, 66(6):1479-1490                *equal contributions



Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S and PE Scherer. 2017.

An Adipo-Biliary-Uridine Axis that Regulates Energy Homeostasis.

Science, 355(6330)



Holland WL, Xia JY, Johnson JA, Sun K, Pearson MJ, Sharma AX, Quittner-Strom E, Tippetts TS, Ruth Gordillo R, Scherer PE. 2017.

Mol. Metab., 6(3):267-275



Holland WL and PE Scherer. 2017.

Structural biology: Receptors grease the metabolic wheels.

Nature, 544(7648):42-44



Ghaben AL and PE Scherer. 2017.

Pas de Deux: Glucagon and Thyroid Hormone Moving in Perfect Synchrony

Circulation Res., 120(5):762-764



Crewe C, An YA, Scherer PE. 2017.

The Ominous Triad of Adipose Tissue Dysfunction:

Inflammation, Fibrosis and Impaired Angiogenesis

  1. Clin Invest., 127(1):74-82.



Collaborative Papers and Reviews 2017-2018:


Stern JH, Arriaga Y, Gupta A, Verma U, Karri S, Syed S, Khosama L, Mansour J, Meyer J, Scherer PE, Beg MS. 2018.

Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Pancreas, in press


Lee C, Kim M, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J. 2018.

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.

J Pathol., in press



Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK. 2018.

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Mol Metab., in press



Neeland IJ, Singh S, McGuire DK, Vega GL, Roddy T, Reilly DF, Castro-Perez J, Kozlitina J, Scherer PE. 2018.

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Diabetologia, 61(12):2570-2579



Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin Y, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. 2018.

HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.

JCI Insight, in press



Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA. 2018.

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Mol Metab., in press



Akgul Y, Constantine R, Bartels M, Scherer P, Davis K, Kenkel JM. 2018.

Utility of Adipocyte Fractions in Fat Grafting in an Athymic Rat Model.

Aesthet Surg J., in press



Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH. 2018.

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Mol Metab., 11:212-217



Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M. 2018.

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress and inflammation in non-alcoholic steatohepatitis.

Diabetes Care, in press



Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV. 2018.

Cell Death Differ., in press



Sun F, You J, Lei Y, Sun L, Garza J, Zhang D, Guo M, Scherer PE, Lodge D, Lu XY. 2018.

Adiponectin, via AdipoR1, modulates ventral tegmental area dopamine neuronal activity and anxiety-related behavior.

Mol. Psychiatry, in press



Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. 2018.

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Nat Med., 24(5):617-627



Wilson RJ, Drake JC, Cui D, Zhang M, Perry HM, Kashatus JA, Kusminski CM, Scherer PE, Kashatus DF, Okusa MD, Yan Z. 2017.

Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy.

Mitochondrion, in press



Udit S, Burton M, Rutkowski JM, Lee S, Bookout AL, Scherer PE, Elmquist JK, Gautron L. 2017.

Nav1.8 neurons are involved in limiting acute phase responses to dietary fat.

Mol Metab.;6(10):1081-1091.



Vernay A, Marchetti A, Sabra A, Jauslin TN, Rosselin M, Scherer PE, Demaurex N, Orci L, Cosson P. 2017.

MitoNEET-dependent formation of intermitochondrial junctions.

Proc Natl Acad Sci U S A;114(31):8277-8282



Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. 2017.

Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.

Am J Pathol. 187(9):1984-1997



Marangoni RG, Masui Y, Fang F, Korman B, Lord G, Lee J, Lakota K, Wei J, Scherer PE, Otvos L, Yamauchi T, Kubota N, Kadowaki T, Asano Y, Sato S, Tourtellotte WG, Varga, J. 2017.

Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target.

Sci Rep.;7(1):4397



Wang M-Y, Yu X, Lee Y, McCorkle SK, Chen S, Li J, Wang ZV, Davidson JA, Scherer PE, Holland WL, Unger RA, and Roth MG. 2017.

Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.

Proc Natl Acad Sci U S A, 114(25):6611-6616



Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell T, Bisetto S, Velasco-Velàzquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE,  Pestell RG. 2017.

Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis.

Cancer Res., 77(13):3391-3405



Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson J, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V. 2017.

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

Nat. Comm., 8:14395



Tanowitz HB, Scherer PE, Mota MM, Figueiredo LM. 2017.

Adipose tissue – a safe haven for parasites?

Trends in Parasitology, 33(4):276-284



Dufurrena Q, Amjad FM, Scherer PE, Weiss LM, Nagajyothi J, Roth J, Tanowitz HB, Kuliawat R. 2017.

Alterations in pancreatic β cell function and Trypanosoma cruzi infection: evidence from human and animal studies.

Parasitol Res., 116(3):827-838



Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. 2017.

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation.

Nat Med., 23(1):79-90



Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. 2017.

Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis.

J Mol Med (Berl)., 95(3):287-297


Zhang D, Wang X, Wang B, Garza J, Fang X, Wang J, Scherer PE, Brenner R, Zhang W, Lu XY. 2017.
Adiponectin modulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors.
Molecular Psychiatry, 22(7):1044-1055