2022 – 2024 Publications             


Primary Papers, Reviews and Commentaries from the Lab in 2021-2023:


Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MF, Marciano DK, Gordillo R, Drucker DJ, Scherer PE.  2024.

Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.

Cell Metabolism, in press




Henriksen K, Genovese F, Reese-Petersen A, Audoly LP, Sun K, Karsdal MA, Scherer PE. 2023.

Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease.

Endocr Rev., in press




Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE. 2023.

Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.

Sci Transl Med.;15(723)




Zhao S, Li N, Xiong W, Li G, He S, Zhang Z, Zhu Q, Jiang N, Ikejiofor C, Zhu Y, Wang MY, Han X, Zhang N, Herrera-Solis C, Kusminski C, An Z, Elmquist JK, Scherer PE. 2024.

Leptin Reduction as a Required Component for Weight Loss.

Diabetes, 73(2):197-210



Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DK, Sun X, An YA, Field B, Lee C, Matsuo E, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess S, Susztak K, Moe OW and Scherer PE. 2023.

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

Nat. Comm., 14(1):6531




Onodera T, Kim DK, Ye R, Wang MY, Chen S, Field B, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R and Scherer PE. 2023.

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.

Mol Metab, 78:101821




Gliniak CM, Pedersen L and Scherer PE. 2023.

Adipose tissue fibrosis: the unwanted houseguest invited by obesity

J Endocrinol., 259(3):e230180




Kruglikov IL and Scherer PE. 2023.

Control of adipose tissue cellularity by the terminal complement cascade

Nat Rev Endocrinol., 19(12):679-680




Brown KA and Scherer PE. 2023

Update on Adipose Tissue and Cancer.

Endocr Rev., 44(6):961-974.



Maya-Ramos L and Scherer PE. 2023.

The role of adipose tissue in cardiovascular pathophysiology.

Cardiometab Syndr J.;3(1):52-63



An YA, Xiong W, Chen S, Bu D, Rutkowski JM, Berger JP, Kusminski CM, Zhang N, An Z, Scherer PE. 2023.

Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model

Mol Metab, 69:101680




Sun K, Li X and Scherer PE. 2023.

Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives

Compr Physiol., 13(1):4387-4407



Joffin N*, Gliniak CM*, Funcke JB, Paschoal VA, Crewe C, Chen S, Gordillo R, Kusminsk CM, Oh DY, Geldenhuys WJ, and Scherer PE. 2022.

* equal contributions

Adipose Tissue Macrophages Exert Systemic Metabolic Control
by Manipulating Local Iron Concentrations

Nature Metabolism, 4(11):1474-1494




Kruglikov IL and Scherer PE. 2022.

Pathophysiology of cellulite: Possible involvement of selective endotoxemia.

Obes Rev., 26:e13517




Li C, Sun X-N, Zhao S and Scherer PE. 2022.

Crosstalk between adipose tissue and the heart: An update

Journal of Translational Internal Medicine, vol.10, no.3, pp.219-226




Zhu Q*, Zhu Y*, Hepler C, Zhang Q, Park JY, Gliniak CM, Henry GH, Crewe C, Bu D, Zhang Z, Zhao S, Morley T, Li N, Kim DS, Strand D, Deng Y, Robino JJ, Varlamov O, Gordillo R, Kolonin MG, Kusminski CM, Gupta RK and Scherer PE. 2022.

* equal contributions

Adipocyte Mesenchymal Transition Contributes to Mammary Tumor Progression

Cell Reports, 40(11):111362



Straub LG and Scherer PE. 2022.

Insulin sensitive human adipocytes for in vitro studies

Nature Reviews Endocrinology, 18(10):591-592




Crewe C, Chen S, Bu D, Gliniak CM, Wernstedt Asterholm I, Yu XX, Funcke JB, Joffin N, Oliveira de Souza C, Oh DY, Varlamov O, Robino JJ, Gordillo R and Scherer PE. 2022.

Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-independent Glucose Uptake via Extracellular Vesicles

Diabetes, 71(12):2496-2512



Kruglikov IL, Zhang Z, and Scherer PE. 2022.                                                                 

Phenotypical Conversions of Dermal Adipocytes as Pathophysiological Steps in Inflammatory Cutaneous Disorders

Int J Mol Sci.; 23(7):3828



Zhu Y, Li N, Huang M, Chen X, An YA, Li J, Zhao S, Funcke J-B, Cao J, He Z, Zhu Q, Zhang Z, Wang ZV, Xu L, Williams KW, Li C, Grove K, Scherer PE. 2022.

Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention

Acta Pharm Sin B, 12(7):3063-3072




Scherer PE, Kirwan JP, Rosen CJ. 2022.

Post-acute sequelae of COVID-19: A metabolic perspective.

Elife, 11:e78200



Gliniak CM, PE Scherer. 2022.

A new signal that shrinks fat

Nat Metabolism, 4(3):305-307




Klein S, Gastaldelli A, Yki-Järvinen H, Scherer PE. 2022.

Why Does Obesity Cause Diabetes?

Cell Met., 34(1):11-20




Colca JR and Scherer PE. 2022.

The Metabolic Syndrome, Thiazolidinediones, and Implications for Intersection of Chronic and Inflammatory Disease

Mol Metab, 55:101409




Zhu Q, An YA and Scherer PE. 2022.

Mitochondrial Regulation and White Adipose Tissue Homeostasis

Trends in Cell Biology; 32, 4, 351-364




Kruglikov IL, Zhang Z, and Scherer PE. 2022.

Skin Aging: Dermal Adipocytes Metabolically Reprogram Dermal Fibroblasts.

Bioessays, 44(1):e2100207





Collaborative Papers and Reviews 2022-2024:


Rosendo-Silva D, Gomes PB, Rodrigues T, Viana S, da Costa AN, Scherer PE, Reis F, Pereira F, Seiça R, Matafome P. 2024.

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.

Metabolism, in press




Perez-Leighton C, Kerr B, Scherer PE, Baudrand R, Cortés V. 2023.

The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour.

Biol Rev Camb Philos Soc., in press



Choe HJ, Oh HR, Bu D, An N, Scherer PE, An Z, Lim S. 2023.

Evaluation of the efficacy of a combination of dapagliflozin and lobeglitazone on glucose concentrations and body fat in patients with type 2 diabetes: Location-F study.

Diabetes Obes Metab. in press



Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O’Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. 2023.

GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.

Diabetes, 73(2):292-305



Lebek S, Caravia XM, Straub LG, Alzhanov D, Tan W, Li H, McAnally JR, Chen K, Xu L, Scherer PE, Liu N, Bassel-Duby R, Olson EN. 2023.

CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model.

J Clin Invest., 134(1):e175164.



Agarwal AK, Tunison K, Vale G, McDonald JG, Li X, Scherer PE, Horton JD and Garg A. 2023.

Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue.

iScience; 26(10):107806.



Maya-Ramos L, Scherer PE and de Lemos JA. 2023.

Small Peptide, Large Implications: Endotrophin in Heart Failure with Preserved Ejection Fraction.

Clin Chem.: 69(8):793-795.



Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Scherer PE, Fang L, Piao HL, Shao M and Gan Z. 2023.

Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes.

Nat Cell Biol., 25(6):848-864



Celen C, Chuang JC, Shen S, Li L, Maggiore G, Jia Y, Luo X, Moore A, Wang Y, Otto JE, Collings CK, Wang Z, Sun X, Nassour I, Park J, Ghaben A, Wang T, Wang SC, Scherer PE, Kadoch C, Zhu H. 2022.

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

Cell Rep., 41(5):111581



Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. 2022.

Ceramides are early responders in metabolic syndrome development in rhesus monkeys.

Sci Rep.; 12(1):9960



Frankl JA, An Y, Sherwood A, Hao G, Huang FY, Thapa P, Clegg DJ, Sun X, Scherer PE, Öz OK. 2022.

Comparison of BMIPP-SPECT/CT to 18FDG-PET/CT for Imaging Brown or Browning Fat in a Preclinical Model.

Int J Mol Sci.; 23(9):4880



Wang X, Zhang G, Dasgupta S, Niewold EL, Li C, Li Q, Luo X, Tan L, Ferdous A, Lorenzi PL, Rothermel BA, Gillette TG, Adams CM, Scherer PE, Hill JA, Wang ZV. 2022.

ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress.

Circ Res.; 131(1):91-105



Zi Z, Zhang Z, Feng Q, Kim C, Wang XD, Scherer PE, Gao J, Levine B, Yu Y. 2022.

Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.

Nat Commun.; 13(1):1760



Perez-Frances M, Abate MV, Baronnier D, Scherer PE, Fujitani Y, Thorel F, Herrera PL. 2022.

Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells.

Cell Rep.; 38(7):110377