2024 – 2025 Publications
Primary Papers, Reviews and Commentaries from the Lab in 2024-2025:
Maya-Ramos L, Scherer PE. 2025.
Adipose Tissue Stress-Related Changes in Mice and Humans with HFpEF.
JACC: Basic to Translational Science, in press
https://authors.elsevier.com/sd/article/S2452-302X(25)00227-X
Kim DK, Funcke JB, Chen S, Min K, Onodera T, Kim M, Velasco J, Virostek M, Walendzik K, Scherer PE. 2025.
ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models.
Experimental & Molecular Medicine, in press
Onodera T, Kim DS, Wang MY, Virostek M, Chen S, Kipp ZA, Bates EA, Li Y, Crewe C, Li C, Sun XN, Zhang Q, Shao M, Shin J, Kusminski CM, Gordillo R, Gupta RK, Hinds TD, Shimomura I, Scherer PE. 2025.
A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectin.
bioRxiv, 2025.07.12.664095
https://pubmed.ncbi.nlm.nih.gov/40791378/
Cartwright BR, Scherer PE. 2025.
Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity.
Diabetes, in press
https://pubmed.ncbi.nlm.nih.gov/40794450/
Funcke JB, Scherer PE. 2025.
Much ado about NAA-thing.
Nat Metabolism, 7(8):1498-1500
http://pubmed.ncbi.nlm.nih.gov/40702166/
Kim DS, Onodera T, Funcke JB, Min K, Zhu Q, Lin Q, Chen S, Joung C, Kim M, Wynn RM, Velasco J, Lee C, Virostek M, Li C, Scherer PE. 2025.
Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice.
J Clin Invest., 135(16):e187202
https://pubmed.ncbi.nlm.nih.gov/40526430/
Le Lay S, Scherer PE. 2025.
Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function.
Cell Rep. 2025 May 22;44(6):115732.
https://pubmed.ncbi.nlm.nih.gov/40408250/
Gliniak CM, Gordillo R, Houm YH, Lin Q, Crewe C, Zhang Z, Field B, Fujikawa T, Virostek M, Zhao S, Zhu Y, Rosen CJ, Horvath TL, Dixit VD, PE Scherer. 2025.
FGF21 Promotes Longevity in Diet-Induced Obesity Through Metabolic Benefits Independent of Growth Suppression.
Cell Metabolism, 37(7):1547-1567
https://authors.elsevier.com/a/1lH795WXUlaYMk
Kruglikov IL, Scherer PE. 2025.
Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis.
Obesity (Silver Spring). 2025 May;33(5):839-850
https://pubmed.ncbi.nlm.nih.gov/40134146/
Straub LG, Funcke JB, Joffin N, Joung C, Al-Ghadban S, Zhao S, Zhu Q, Kruglikov IL, Zhu Y, Langlais PR, Gordillo R, Herbst KL, Scherer PE, 2025.
Defining lipedema’s molecular hallmarks by multi-omics approach for disease prediction in women.
Metabolism 168:156191
https://pubmed.ncbi.nlm.nih.gov/40097137/
https://doi.org/10.1016/j.metabol.2025.156191
Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld A, Campbell JE, Coghlan MP, D’Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. 2025.
Glucose-dependent insulinotropic polypeptide (GIP).
Mol Metab., 95:102118
https://pubmed.ncbi.nlm.nih.gov/40024571/
Kim DK, Funcke JB, Chen S, Min K, Onodera T, Kim M, Velasco J, Virostek M, Walendzik K, Scherer PE. 2025.
ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models.
bioRxiv [Preprint]. 2025 Feb 26: https://doi.org/10.1101/2025.02.20.639288
https://www.biorxiv.org/content/10.1101/2025.02.20.639288v1
https://pubmed.ncbi.nlm.nih.gov/40060507/
Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. 2025.
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.
Nat Aging, 5(4):576-587
https://pubmed.ncbi.nlm.nih.gov/39972172/
Zhao S, Zhu QZ, Lee WH, Funcke JB, Zhang Z, Wang MY, Lin Q, Field B, Sun X, Li G, Ekane M, Onodera T, Li N, Zhu Y, Kusminski CM, Terry D Hinds TD, Scherer PE. 2025.
The Adiponectin-PPARγ Axis in Hepatic Stellate Cells Regulates Liver Fibrosis.
Cell Reports, 44(1):115165
https://pubmed.ncbi.nlm.nih.gov/39792554/
Yu X, Chen S, Funcke JB, Straub GS, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. 2025.
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Cell Metabolism, 37(1):187-204
https://authors.elsevier.com/c/1kDHh5WXUlWkgC
https://pubmed.ncbi.nlm.nih.gov/39642881/
Li C, Sun XN, Funcke JB, Vanharanta L, Joffin N, Li Y, Prasanna X, Paredes M, Joung C, Gordillo R, Vörös C, Kulig W, Straub L, Chen S, Velasco J, Cobb A, Padula D, Wang MY, Onodera T, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Goodman JM, Wynn RM, Vattulainen I, Han Y, Ikonen E, Scherer PE. 2024.
Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex.
bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605195
https://pubmed.ncbi.nlm.nih.gov/39211078/
Yan LI Y, Toshiharu Onodera T, Philipp E. Scherer PE. 2024.
Hormone of the Month: Adiponectin
Trends in Endocrinology and Metabolism, 35(7):674-675
https://authors.elsevier.com/a/1jKOy_NkAfhcjw
https://pubmed.ncbi.nlm.nih.gov/38981443/
Kusminski CM, Perez-Tilve D, Müller TD, DiMarchi R, Tschöp MH and Scherer PE. 2024.
Transforming Obesity: The Advancement of Multi-Receptor Drugs.
Cell 187(15):3829-3853
https://authors.elsevier.com/a/1jUX4L7PXqR4X
Zhu QZ, Chen S, Funcke, JB, Straub LG, Lin Q, Zhao S, Joung C, Zhang, Z, Kim D, Li N., Gliniak C, Lee C, Alberto Cebrian-Serrano A, Pedersen L, Halberg N, Gordillo R, Kusminski CM, and Scherer PE. 2024.
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
Nature Metabolism, 6(7):1347-1366
https://pubmed.ncbi.nlm.nih.gov/38961186/
Zhu QZ and Scherer PE. 2024.
Ceramides and Atherosclerotic Cardiovascular Disease: A Current Perspective.
Circulation, 149, 21, 1624–1626.
https://pubmed.ncbi.nlm.nih.gov/38768269/
Kruglikov IL and Scherer PE. 2024.
Is the endotoxin–complement cascade the major driver in lipedema?
Trends Endocrinol Metab., 35(9):769-780
https://authors.elsevier.com/a/1i-uP3jDgWq35c
https://pubmed.ncbi.nlm.nih.gov/38688780/
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MF, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. 2024.
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Cell Metabolism, 36(3):575-597
https://authors.elsevier.com/a/1iRkK5WXUlSwbM
https://pubmed.ncbi.nlm.nih.gov/38237602/
Henriksen K, Genovese F, Reese-Petersen A, Audoly LP, Sun K, Karsdal MA, Scherer PE. 2024.
Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease.
Endocr Rev., 45(3):361-378
https://pubmed.ncbi.nlm.nih.gov/38091968/
Zhao S, Li N, Xiong W, Li G, He S, Zhang Z, Zhu Q, Jiang N, Ikejiofor C, Zhu Y, Wang MY, Han X, Zhang N, Herrera-Solis C, Kusminski C, An Z, Elmquist JK, Scherer PE. 2024.
Leptin Reduction as a Required Component for Weight Loss.
Diabetes, 73(2):197-210
https://pubmed.ncbi.nlm.nih.gov/37935033/
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Collaborative Papers and Reviews 2024-2025:
Griesel BA, Williams K, Ahsan N, Scherer PE, Olson AL, Sparling DP. 2025.
CRISPLD2, a novel insulin-sensitizing adipokine that alters adipocyte size.
Obesity, in press
http://doi.org/10.1002/oby.24342
https://pubmed.ncbi.nlm.nih.gov/40855979/
Retnakaran R, Bu D, Pu J, Connelly PW, Hanley AJ, Zhang N, An Z, Zinman B, Scherer PE. Serum endotrophin relates to blood pressure in young South Asian women but not white women: evidence of ethnic variation in its early vascular implications.
BMC Cardiovasc Disord 2025, in press
Chen X, Li H, Deng Y, Meng J, Zhao S, Wooton-Kee CR, Gao X, Dong B, Guan D, Wu C, Scherer PE, Zhu Y. 2025.
The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis.
Biomed Pharmacother;190:118427
https://pubmed.ncbi.nlm.nih.gov/40774020/
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. 2025.
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
bioRxiv [Preprint]
https://pubmed.ncbi.nlm.nih.gov/40799539/
Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. 2025.
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.
Nat Aging.;5(4):576-587.
https://pubmed.ncbi.nlm.nih.gov/39972172/
Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld AL, Campbell JE, Coghlan MP, D’Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. 2025.
Glucose-dependent insulinotropic polypeptide (GIP).
Mol Metab.;95:102118
https://pubmed.ncbi.nlm.nih.gov/40024571/
Chen X, Li H, Deng Y, Meng J, Zhao S, Wooton-Kee CR, Gao X, Dong B, Guan D, Wu C, Scherer PE, Zhu Y. 2025.
The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis
bioRxiv [Preprint]: 2025.05.19.654778
https://pubmed.ncbi.nlm.nih.gov/40475534/
Alba DL, Choi MK, Abdellatif A, Brown Mayfield S, Pham TAT, Berrios D, Rodriguez A, Ewing M, Figueroa T, Gonzalez-Vargas J, Zhang N, An Z, Bu D, Deeks SG, Scherer PE, Hunt PW, Koliwad SK. 2025.
A Distinct Form of Subcutaneous Fat Fibrosis Predicts Insulin Resistance in People with HIV.
medRxiv [Preprint]. 2025:2025.05.13.25327547
https://pubmed.ncbi.nlm.nih.gov/40463535/
Giugni F, Maya-Ramos L, Yang Y, Arthur V, Claggett B, Gillette T, Scherer PE,
Hill JA, de Lemos JA, Hoogeveen R, Ballantyne CM, Ndumele CE, Yu B, Shah AM. 2025.
PLASMA ENDOTROPHIN IS ASSOCIATED WITH RISK OF HFPEF BUT NOT HFrEF: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
JACC, Volume 85, Issue 12, Suppl A
https://www.sciencedirect.com/science/article/pii/S0735109725020078?via%3Dihub
Liu W, Mao R, Nga Le TH, West G, Varadharajan V, Banerjee R, Doyon G, Mukherjee P, Nguyen QT, Mulya A, Rennison JH, Gordon IO, Cruise M, Hu S, Czarnecki D, Plesec T, Chandra J, Banerjee S, Wang J, Massey WJ, Goren I, Lin SN, Kurada S, Cohen BL, Qazi T, Holubar SD, Lipman J, Kanters A, Gliniak CM, Scherer PE, Chen MH, Siegmund B, Ivanov AI, Fiocchi C, Van Wagoner DR, Brown JM, Rieder F. 2025.
Creeping Fat-Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease.
Gastroenterology;168(3):508-524
https://pubmed.ncbi.nlm.nih.gov/39522890/
Samms RJ, Kusminski CM. 2025.
A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity.
Annu Rev Physiol; 87(1):279-299
https://pubmed.ncbi.nlm.nih.gov/39546586/
Flannery AH, Bu D, Botkins M, Gianella F, Zhang N, An Z, Moe OW, Scherer PE, Neyra JA. 2024.
Endotrophin as a Biomarker for Severe Acute Kidney Injury and Major Adverse Kidney Events.
Kidney360, 5(8):1087-1093
https://pubmed.ncbi.nlm.nih.gov/39024016/
Cefalu WT, Franks PW, Rosenblum ND, Zaghloul NA, Florez JC, Giorgino F, Ji L, Ma RCW, Mathieu C, Misra S, Ramirez AH, Roden M, Scherer PE, Sheu WH, Stehouwer CDA, Woo M, Pragnell M, Anand SS, Carnethon M, Chambers JC, Dennis JM, Gloyn AL, Herder C, Holt RIG, Manuel DG, Redondo MJ, Tandon N, Tsang JS, Udler MS, Rich SS. 2024
A global initiative to deliver precision health in diabetes.
Nat Med.; 30(7):1819-1822
https://pubmed.ncbi.nlm.nih.gov/38992126/
Lee PC, Jung IH, Thussu S, Patel V, Wagoner R, Burks KH, Amrute J, Elenbaas JS, Kang CJ, Young EP, Scherer PE, Stitziel NO. 2024.
Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.
iScience; 27(7):110104.
https://pubmed.ncbi.nlm.nih.gov/38989470/
Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. 2024.
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
Circulation; 150(13):1010-1029
https://pubmed.ncbi.nlm.nih.gov/38836349/
Robino JJ, Plekhanov AP, Zhu Q, Jensen MD, Scherer PE, Roberts CT, Varlamov O. 2024.
Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue.
Obesity (Silver Spring); 32(4):723-732
https://pubmed.ncbi.nlm.nih.gov/38321231/
http://dx.doi.org/10.1002/oby.23992
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O’Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. 2023.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Diabetes, 73(2):292-305.
https://pubmed.ncbi.nlm.nih.gov/37934926/
Rosendo-Silva D, Gomes PB, Rodrigues T, Viana S, da Costa AN, Scherer PE, Reis F, Pereira F, Seiça R, Matafome P. 2024.
Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.
Metabolism, 153:155788
https://authors.elsevier.com/sd/article/S0026-0495(24)00014-3
https://pubmed.ncbi.nlm.nih.gov/38219974/
Perez-Leighton C, Kerr B, Scherer PE, Baudrand R, Cortés V. 2024.
The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour.
Biol Rev Camb Philos Soc., Biol. Rev., 99, pp. 653–674.
https://pubmed.ncbi.nlm.nih.gov/38072002/