2023 – 2025 Publications
Primary Papers, Reviews and Commentaries from the Lab in 2023-2025:
Kruglikov IL, Scherer PE. 2025.
Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis.
Obesity (Silver Spring). 2025 May;33(5):839-850
https://pubmed.ncbi.nlm.nih.gov/40134146/
Straub LG, Funcke JB, Joffin N, Joung C, Al-Ghadban S, Zhao S, Zhu Q, Kruglikov IL, Zhu Y, Langlais PR, Gordillo R, Herbst KL, Scherer PE, 2025.
Defining lipedema’s molecular hallmarks by multi-omics approach for disease prediction in women.
Metabolism 168:156191
https://pubmed.ncbi.nlm.nih.gov/40097137/
https://doi.org/10.1016/j.metabol.2025.156191
Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld A, Campbell JE, Coghlan MP, D’Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. 2025.
Glucose-dependent insulinotropic polypeptide (GIP).
Mol Metab., 95:102118
https://pubmed.ncbi.nlm.nih.gov/40024571/
Kim DK, Funcke JB, Chen S, Min K, Onodera T, Kim M, Velasco J, Virostek M, Walendzik K, Scherer PE. 2025.
ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models.
bioRxiv [Preprint]. 2025 Feb 26: https://doi.org/10.1101/2025.02.20.639288
https://www.biorxiv.org/content/10.1101/2025.02.20.639288v1
Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. 2025.
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.
Nat Aging, 5(4):576-587
https://pubmed.ncbi.nlm.nih.gov/39972172/
Zhao S, Zhu QZ, Lee WH, Funcke JB, Zhang Z, Wang MY, Lin Q, Field B, Sun X, Li G, Ekane M, Onodera T, Li N, Zhu Y, Kusminski CM, Terry D Hinds TD, Scherer PE. 2025.
The Adiponectin-PPARγ Axis in Hepatic Stellate Cells Regulates Liver Fibrosis.
Cell Reports, 44(1):115165
https://pubmed.ncbi.nlm.nih.gov/39792554/
Yu X, Chen S, Funcke JB, Straub GS, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. 2025.
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Cell Metabolism, 37(1):187-204
https://authors.elsevier.com/c/1kDHh5WXUlWkgC
https://pubmed.ncbi.nlm.nih.gov/39642881/
Li C, Sun XN, Funcke JB, Vanharanta L, Joffin N, Li Y, Prasanna X, Paredes M, Joung C, Gordillo R, Vörös C, Kulig W, Straub L, Chen S, Velasco J, Cobb A, Padula D, Wang MY, Onodera T, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Goodman JM, Wynn RM, Vattulainen I, Han Y, Ikonen E, Scherer PE. 2024.
Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex.
bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605195
https://pubmed.ncbi.nlm.nih.gov/39211078/
Yan LI Y, Toshiharu Onodera T, Philipp E. Scherer PE. 2024.
Hormone of the Month: Adiponectin
Trends in Endocrinology and Metabolism, 35(7):674-675
https://authors.elsevier.com/a/1jKOy_NkAfhcjw
https://pubmed.ncbi.nlm.nih.gov/38981443/
Kusminski CM, Perez-Tilve D, Müller TD, DiMarchi R, Tschöp MH and Scherer PE. 2024.
Transforming Obesity: The Advancement of Multi-Receptor Drugs.
Cell 187(15):3829-3853
https://authors.elsevier.com/a/1jUX4L7PXqR4X
Zhu QZ, Chen S, Funcke, JB, Straub LG, Lin Q, Zhao S, Joung C, Zhang, Z, Kim D, Li N., Gliniak C, Lee C, Alberto Cebrian-Serrano A, Pedersen L, Halberg N, Gordillo R, Kusminski CM, and Scherer PE. 2024.
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels
Nature Metabolism, 6(7):1347-1366
https://pubmed.ncbi.nlm.nih.gov/38961186/
Zhu QZ and Scherer PE. 2024.
Ceramides and Atherosclerotic Cardiovascular Disease: A Current Perspective
Circulation, 149, 21, 1624–1626.
https://pubmed.ncbi.nlm.nih.gov/38768269/
Kruglikov IL and Scherer PE. 2024.
Is the endotoxin–complement cascade the major driver in lipedema?
Trends Endocrinol Metab., 35(9):769-780
https://authors.elsevier.com/a/1i-uP3jDgWq35c
https://pubmed.ncbi.nlm.nih.gov/38688780/
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MF, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. 2024.
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Cell Metabolism, 36(3):575-597
https://authors.elsevier.com/a/1iRkK5WXUlSwbM
https://pubmed.ncbi.nlm.nih.gov/38237602/
Henriksen K, Genovese F, Reese-Petersen A, Audoly LP, Sun K, Karsdal MA, Scherer PE. 2023.
Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease.
Endocr Rev., 45(3):361-378
https://pubmed.ncbi.nlm.nih.gov/38091968/
Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE. 2023.
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.
Sci Transl Med.;15(723):eade8460
https://www.science.org/stoken/author-tokens/ST-1561/full
https://pubmed.ncbi.nlm.nih.gov/37992151/
Zhao S, Li N, Xiong W, Li G, He S, Zhang Z, Zhu Q, Jiang N, Ikejiofor C, Zhu Y, Wang MY, Han X, Zhang N, Herrera-Solis C, Kusminski C, An Z, Elmquist JK, Scherer PE. 2024.
Leptin Reduction as a Required Component for Weight Loss.
Diabetes, 73(2):197-210
https://pubmed.ncbi.nlm.nih.gov/37935033/
Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DK, Sun X, An YA, Field B, Lee C, Matsuo E, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess S, Susztak K, Moe OW and Scherer PE. 2023.
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.
Nat. Comm., 14(1):6531
https://pubmed.ncbi.nlm.nih.gov/37848446/
Onodera T, Kim DK, Ye R, Wang MY, Chen S, Field B, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R and Scherer PE. 2023.
Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Mol Metab, 78:101821
https://authors.elsevier.com/sd/article/S2212-8778(23)00155-2
https://pubmed.ncbi.nlm.nih.gov/37806486/
Gliniak CM, Pedersen L and Scherer PE. 2023.
Adipose tissue fibrosis: the unwanted houseguest invited by obesity
J Endocrinol., 259(3):e230180
https://doi.org/10.1530/JOE-23-0180
https://pubmed.ncbi.nlm.nih.gov/37754915/
Kruglikov IL and Scherer PE. 2023.
Control of adipose tissue cellularity by the terminal complement cascade
Nat Rev Endocrinol., 19(12):679-680
https://pubmed.ncbi.nlm.nih.gov/37696916/
Brown KA and Scherer PE. 2023
Update on Adipose Tissue and Cancer.
Endocr Rev., 44(6):961-974.
https://pubmed.ncbi.nlm.nih.gov/37260403/
Maya-Ramos L and Scherer PE. 2023.
The role of adipose tissue in cardiovascular pathophysiology.
Cardiometab Syndr J.;3(1):52-63
https://www.e-cmsj.org/DOIx.php?id=10.51789/cmsj.2023.3.e9
An YA, Xiong W, Chen S, Bu D, Rutkowski JM, Berger JP, Kusminski CM, Zhang N, An Z, Scherer PE. 2023.
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model
Mol Metab, 69:101680
https://doi.org/10.1016/j.molmet.2023.101680
https://pubmed.ncbi.nlm.nih.gov/36696925/
Sun K, Li X and Scherer PE. 2023.
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Compr Physiol., 13(1):4387-4407
https://pubmed.ncbi.nlm.nih.gov/36715281/
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Collaborative Papers and Reviews 2023-2025:
Giugni F, Maya-Ramos L, Yang Y, Arthur V, Claggett B, Gillette T, Scherer PE,
Hill JA, de Lemos JA, Hoogeveen R, Ballantyne CM, Ndumele CE, Yu B, Shah AM. 2025.
PLASMA ENDOTROPHIN IS ASSOCIATED WITH RISK OF HFPEF BUT NOT HFrEF: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
JACC, Volume 85, Issue 12, Suppl A
https://www.sciencedirect.com/science/article/pii/S0735109725020078?via%3Dihub
Liu W, Mao R, Nga Le TH, West G, Varadharajan V, Banerjee R, Doyon G, Mukherjee P, Nguyen QT, Mulya A, Rennison JH, Gordon IO, Cruise M, Hu S, Czarnecki D, Plesec T, Chandra J, Banerjee S, Wang J, Massey WJ, Goren I, Lin SN, Kurada S, Cohen BL, Qazi T, Holubar SD, Lipman J, Kanters A, Gliniak CM, Scherer PE, Chen MH, Siegmund B, Ivanov AI, Fiocchi C, Van Wagoner DR, Brown JM, Rieder F. 2024.
CREEPING FAT-DERIVED FREE FATTY ACIDS INDUCE HYPERPLASIA OF INTESTINAL MUSCULARIS PROPRIA MUSCLE CELLS – A NOVEL LINK BETWEEN FAT AND INTESTINAL STRICTURE FORMATION IN CROHN’S DISEASE.
Gastroenterology, 168(3):508-524
https://pubmed.ncbi.nlm.nih.gov/39522890/
Samms RJ, Kusminski CM. 2025.
A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity.
Annu Rev Physiol; 87(1):279-299
https://pubmed.ncbi.nlm.nih.gov/39546586/
Flannery AH, Bu D, Botkins M, Gianella F, Zhang N, An Z, Moe OW, Scherer PE, Neyra JA. 2024.
Endotrophin as a Biomarker for Severe Acute Kidney Injury and Major Adverse Kidney Events.
Kidney360, 5(8):1087-1093
https://pubmed.ncbi.nlm.nih.gov/39024016/
Cefalu WT, Franks PW, Rosenblum ND, Zaghloul NA, Florez JC, Giorgino F, Ji L, Ma RCW, Mathieu C, Misra S, Ramirez AH, Roden M, Scherer PE, Sheu WH, Stehouwer CDA, Woo M, Pragnell M, Anand SS, Carnethon M, Chambers JC, Dennis JM, Gloyn AL, Herder C, Holt RIG, Manuel DG, Redondo MJ, Tandon N, Tsang JS, Udler MS, Rich SS. 2024
A global initiative to deliver precision health in diabetes.
Nat Med.; 30(7):1819-1822
https://pubmed.ncbi.nlm.nih.gov/38992126/
Lee PC, Jung IH, Thussu S, Patel V, Wagoner R, Burks KH, Amrute J, Elenbaas JS, Kang CJ, Young EP, Scherer PE, Stitziel NO. 2024.
Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.
iScience; 27(7):110104.
https://pubmed.ncbi.nlm.nih.gov/38989470/
Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. 2024.
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
Circulation; 150(13):1010-1029
https://pubmed.ncbi.nlm.nih.gov/38836349/
Robino JJ, Plekhanov AP, Zhu Q, Jensen MD, Scherer PE, Roberts CT, Varlamov O. 2024.
Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue.
Obesity (Silver Spring); 32(4):723-732
https://pubmed.ncbi.nlm.nih.gov/38321231/
http://dx.doi.org/10.1002/oby.23992
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O’Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. 2023.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Diabetes, 73(2):292-305.
https://pubmed.ncbi.nlm.nih.gov/37934926/
Rosendo-Silva D, Gomes PB, Rodrigues T, Viana S, da Costa AN, Scherer PE, Reis F, Pereira F, Seiça R, Matafome P. 2024.
Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.
Metabolism, 153:155788
https://authors.elsevier.com/sd/article/S0026-0495(24)00014-3
https://pubmed.ncbi.nlm.nih.gov/38219974/
Perez-Leighton C, Kerr B, Scherer PE, Baudrand R, Cortés V. 2024.
The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour.
Biol Rev Camb Philos Soc., Biol. Rev., 99, pp. 653–674.
https://pubmed.ncbi.nlm.nih.gov/38072002/
Choe HJ, Oh HR, Bu D, An N, Scherer PE, An Z, Lim S. 2023.
Evaluation of the efficacy of a combination of dapagliflozin and lobeglitazone on glucose concentrations and body fat in patients with type 2 diabetes: Location-F study.
Diabetes Obes Metab. 26(3):1114-1119
https://pubmed.ncbi.nlm.nih.gov/38073421/
Lebek S, Caravia XM, Straub LG, Alzhanov D, Tan W, Li H, McAnally JR, Chen K, Xu L, Scherer PE, Liu N, Bassel-Duby R, Olson EN. 2023.
CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model.
J Clin Invest., 134(1):e175164.
https://pubmed.ncbi.nlm.nih.gov/37856214/
Agarwal AK, Tunison K, Vale G, McDonald JG, Li X, Scherer PE, Horton JD and Garg A. 2023.
Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue.
iScience; 26(10):107806.
https://pubmed.ncbi.nlm.nih.gov/37752957/
Maya-Ramos L, Scherer PE and de Lemos JA. 2023.
Small Peptide, Large Implications: Endotrophin in Heart Failure with Preserved Ejection Fraction.
Clin Chem.: 69(8):793-795.
https://pubmed.ncbi.nlm.nih.gov/36738263/
Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Scherer PE, Fang L, Piao HL, Shao M and Gan Z. 2023.
Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes.
Nat Cell Biol., 25(6):848-864
https://pubmed.ncbi.nlm.nih.gov/37217599/