2022 – 2024 Publications
Primary Papers, Reviews and Commentaries from the Lab in 2021-2024:
Hormone of the Month: Adiponectin
Yan LI Y, Toshiharu Onodera T, Philipp E. Scherer PE. 2024.
Trends in Endocrinology and Metabolism, in press
https://authors.elsevier.com/a/1jKOy_NkAfhcjw
https://pubmed.ncbi.nlm.nih.gov/38981443/
Kusminski CM, Perez-Tilve D, Müller TD, DiMarchi R, Tschöp MH and Scherer PE. 2024.
Transforming Obesity: The Advancement of Multi-Receptor Drugs
Cell 187, July 25, 2024 in press
https://authors.elsevier.com/a/1jUX4L7PXqR4X
Zhu QZ, Chen S, Funcke, JB, Straub LG, Lin Q, Zhao S, Joung C, Zhang, Z, Kim D, Li N., Gliniak C, Lee C, Alberto Cebrian-Serrano A, Pedersen L, Halberg N, Gordillo R, Kusminski CM, and Scherer PE. 2024.
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.
Nature Metabolism, in press
https://pubmed.ncbi.nlm.nih.gov/38961186/
Zhu QZ and Scherer PE. 2024.
Ceramides and Atherosclerotic Cardiovascular Disease: A Current Perspective
Circulation, 149, 21, 1624–1626.
https://pubmed.ncbi.nlm.nih.gov/38768269/
Kruglikov IL and Scherer PE. 2024.
Is the endotoxin–complement cascade the major driver in lipedema?
Trends in Endocrinology & Metabolism, in press
https://authors.elsevier.com/a/1i-uP3jDgWq35c
https://pubmed.ncbi.nlm.nih.gov/38688780/
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MF, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. 2024.
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Cell Metabolism, in press
https://authors.elsevier.com/a/1iRkK5WXUlSwbM
https://pubmed.ncbi.nlm.nih.gov/38237602/
Henriksen K, Genovese F, Reese-Petersen A, Audoly LP, Sun K, Karsdal MA, Scherer PE. 2023.
Endotrophin, a Key Marker and Driver for Fibroinflammatory Disease.
Endocr Rev., in press
https://pubmed.ncbi.nlm.nih.gov/38091968/
Zhao S, Lin Q, Xiong W, Li L, Straub L, Zhang D, Zapata R, Zhu Q, Sun XN, Zhang Z, Funcke JB, Li C, Chen S, Zhu Y, Jiang N, Li G, Xu Z, Wyler SC, Wang MY, Bai J, Han X, Kusminski CM, Zhang N, An Z, Elmquist JK, Osborn O, Liu C, Scherer PE. 2023.
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders.
Sci Transl Med.;15(723)
https://www.science.org/stoken/author-tokens/ST-1561/full
https://pubmed.ncbi.nlm.nih.gov/37992151/
Zhao S, Li N, Xiong W, Li G, He S, Zhang Z, Zhu Q, Jiang N, Ikejiofor C, Zhu Y, Wang MY, Han X, Zhang N, Herrera-Solis C, Kusminski C, An Z, Elmquist JK, Scherer PE. 2024.
Leptin Reduction as a Required Component for Weight Loss.
Diabetes, 73(2):197-210
https://pubmed.ncbi.nlm.nih.gov/37935033/
Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DK, Sun X, An YA, Field B, Lee C, Matsuo E, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess S, Susztak K, Moe OW and Scherer PE. 2023.
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.
Nat. Comm., 14(1):6531
https://pubmed.ncbi.nlm.nih.gov/37848446/
Onodera T, Kim DK, Ye R, Wang MY, Chen S, Field B, Straub L, Sun XN, Li C, Lee C, Paredes M, Crewe C, Zhao S, Kusminski CM, Gordillo R and Scherer PE. 2023.
Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells.
Mol Metab, 78:101821
https://authors.elsevier.com/sd/article/S2212-8778(23)00155-2
https://pubmed.ncbi.nlm.nih.gov/37806486/
Gliniak CM, Pedersen L and Scherer PE. 2023.
Adipose tissue fibrosis: the unwanted houseguest invited by obesity
J Endocrinol., 259(3):e230180
https://doi.org/10.1530/JOE-23-0180
https://pubmed.ncbi.nlm.nih.gov/37754915/
Kruglikov IL and Scherer PE. 2023.
Control of adipose tissue cellularity by the terminal complement cascade
Nat Rev Endocrinol., 19(12):679-680
https://pubmed.ncbi.nlm.nih.gov/37696916/
Brown KA and Scherer PE. 2023
Update on Adipose Tissue and Cancer.
Endocr Rev., 44(6):961-974.
https://pubmed.ncbi.nlm.nih.gov/37260403/
Maya-Ramos L and Scherer PE. 2023.
The role of adipose tissue in cardiovascular pathophysiology.
Cardiometab Syndr J.;3(1):52-63
https://www.e-cmsj.org/DOIx.php?id=10.51789/cmsj.2023.3.e9
An YA, Xiong W, Chen S, Bu D, Rutkowski JM, Berger JP, Kusminski CM, Zhang N, An Z, Scherer PE. 2023.
Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model
Mol Metab, 69:101680
https://doi.org/10.1016/j.molmet.2023.101680
https://pubmed.ncbi.nlm.nih.gov/36696925/
Sun K, Li X and Scherer PE. 2023.
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Compr Physiol., 13(1):4387-4407
https://pubmed.ncbi.nlm.nih.gov/36715281/
Joffin N*, Gliniak CM*, Funcke JB, Paschoal VA, Crewe C, Chen S, Gordillo R, Kusminsk CM, Oh DY, Geldenhuys WJ, and Scherer PE. 2022.
* equal contributions
Adipose Tissue Macrophages Exert Systemic Metabolic Control
by Manipulating Local Iron Concentrations
Nature Metabolism, 4(11):1474-1494
https://pubmed.ncbi.nlm.nih.gov/36329217/
Kruglikov IL and Scherer PE. 2022.
Pathophysiology of cellulite: Possible involvement of selective endotoxemia.
Obes Rev., 26:e13517
http://dx.doi.org/10.1111/obr.13517
https://pubmed.ncbi.nlm.nih.gov/36285892/
Li C, Sun X-N, Zhao S and Scherer PE. 2022.
Crosstalk between adipose tissue and the heart: An update
Journal of Translational Internal Medicine, vol.10, no.3, pp.219-226
https://pubmed.ncbi.nlm.nih.gov/36776231/
https://sciendo.com/article/10.2478/jtim-2022-0039?tab=article
Zhu Q*, Zhu Y*, Hepler C, Zhang Q, Park JY, Gliniak CM, Henry GH, Crewe C, Bu D, Zhang Z, Zhao S, Morley T, Li N, Kim DS, Strand D, Deng Y, Robino JJ, Varlamov O, Gordillo R, Kolonin MG, Kusminski CM, Gupta RK and Scherer PE. 2022.
* equal contributions
Adipocyte Mesenchymal Transition Contributes to Mammary Tumor Progression
Cell Reports, 40(11):111362
https://pubmed.ncbi.nlm.nih.gov/36103820/
Straub LG and Scherer PE. 2022.
Insulin sensitive human adipocytes for in vitro studies
Nature Reviews Endocrinology, 18(10):591-592
https://pubmed.ncbi.nlm.nih.gov/35896823/
Crewe C, Chen S, Bu D, Gliniak CM, Wernstedt Asterholm I, Yu XX, Funcke JB, Joffin N, Oliveira de Souza C, Oh DY, Varlamov O, Robino JJ, Gordillo R and Scherer PE. 2022.
Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-independent Glucose Uptake via Extracellular Vesicles
Diabetes, 71(12):2496-2512
https://pubmed.ncbi.nlm.nih.gov/35880782/
Kruglikov IL, Zhang Z, and Scherer PE. 2022.
Phenotypical Conversions of Dermal Adipocytes as Pathophysiological Steps in Inflammatory Cutaneous Disorders
Int J Mol Sci.; 23(7):3828
https://www.mdpi.com/1422-0067/23/7/3828/pdf
Zhu Y, Li N, Huang M, Chen X, An YA, Li J, Zhao S, Funcke J-B, Cao J, He Z, Zhu Q, Zhang Z, Wang ZV, Xu L, Williams KW, Li C, Grove K, Scherer PE. 2022.
Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention
Acta Pharm Sin B, 12(7):3063-3072
https://pubmed.ncbi.nlm.nih.gov/35865093/
https://doi.org/10.1016/j.apsb.2022.02.020
Scherer PE, Kirwan JP, Rosen CJ. 2022.
Post-acute sequelae of COVID-19: A metabolic perspective.
Elife, 11:e78200
https://pubmed.ncbi.nlm.nih.gov/35318939/
Gliniak CM, PE Scherer. 2022.
A new signal that shrinks fat
Nat Metabolism, 4(3):305-307
https://pubmed.ncbi.nlm.nih.gov/35288723/
Klein S, Gastaldelli A, Yki-Järvinen H, Scherer PE. 2022.
Why Does Obesity Cause Diabetes?
Cell Met., 34(1):11-20
https://authors.elsevier.com/c/1eMWX5WXUlLIhk
https://pubmed.ncbi.nlm.nih.gov/34986330/
Colca JR and Scherer PE. 2022.
The Metabolic Syndrome, Thiazolidinediones, and Implications for Intersection of Chronic and Inflammatory Disease
Mol Metab, 55:101409
https://doi.org/10.1016/j.molmet.2021.101409
https://pubmed.ncbi.nlm.nih.gov/34863942/
Zhu Q, An YA and Scherer PE. 2022.
Mitochondrial Regulation and White Adipose Tissue Homeostasis
Trends in Cell Biology; 32, 4, 351-364
https://doi.org/10.1016/j.tcb.2021.10.008
https://pubmed.ncbi.nlm.nih.gov/34810062/
Kruglikov IL, Zhang Z, and Scherer PE. 2022.
Skin Aging: Dermal Adipocytes Metabolically Reprogram Dermal Fibroblasts.
Bioessays, 44(1):e2100207
http://doi.org/10.1002/bies.202100207
https://pubmed.ncbi.nlm.nih.gov/34766637/
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Collaborative Papers and Reviews 2022-2024:
Flannery AH, Bu D, Botkins M, Gianella F, Zhang N, An Z, Moe OW, Scherer PE, Neyra JA. 2024.
Endotrophin as a Biomarker for Severe Acute Kidney Injury and Major Adverse Kidney Events.
Kidney360, in press
https://pubmed.ncbi.nlm.nih.gov/39024016/
Cefalu WT, Franks PW, Rosenblum ND, Zaghloul NA, Florez JC, Giorgino F, Ji L, Ma RCW, Mathieu C, Misra S, Ramirez AH, Roden M, Scherer PE, Sheu WH, Stehouwer CDA, Woo M, Pragnell M, Anand SS, Carnethon M, Chambers JC, Dennis JM, Gloyn AL, Herder C, Holt RIG, Manuel DG, Redondo MJ, Tandon N, Tsang JS, Udler MS, Rich SS. 2024
A global initiative to deliver precision health in diabetes.
Nat Med.; 30(7):1819-1822
https://pubmed.ncbi.nlm.nih.gov/38992126/
Lee PC, Jung IH, Thussu S, Patel V, Wagoner R, Burks KH, Amrute J, Elenbaas JS, Kang CJ, Young EP, Scherer PE, Stitziel NO. 2024.
Instrumental variable and colocalization analyses identify endotrophin and HTRA1 as potential therapeutic targets for coronary artery disease.
iScience; 27(7):110104.
https://pubmed.ncbi.nlm.nih.gov/38989470/
Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. 2024.
IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts.
Circulation. In press
https://pubmed.ncbi.nlm.nih.gov/38836349/
Robino JJ, Plekhanov AP, Zhu Q, Jensen MD, Scherer PE, Roberts CT, Varlamov O. 2024.
Adipose Tissue Analysis Toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue.
Obesity (Silver Spring); 32(4):723-732
https://pubmed.ncbi.nlm.nih.gov/38321231/
http://dx.doi.org/10.1002/oby.23992
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O’Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. 2023.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Diabetes, 73(2):292-305.
https://pubmed.ncbi.nlm.nih.gov/37934926/
Rosendo-Silva D, Gomes PB, Rodrigues T, Viana S, da Costa AN, Scherer PE, Reis F, Pereira F, Seiça R, Matafome P. 2024.
Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.
Metabolism, 153:155788
https://authors.elsevier.com/sd/article/S0026-0495(24)00014-3
https://pubmed.ncbi.nlm.nih.gov/38219974/
Perez-Leighton C, Kerr B, Scherer PE, Baudrand R, Cortés V. 2024.
The interplay between leptin, glucocorticoids, and GLP1 regulates food intake and feeding behaviour.
Biol Rev Camb Philos Soc., Biol. Rev., 99, pp. 653–674.
https://pubmed.ncbi.nlm.nih.gov/38072002/
Choe HJ, Oh HR, Bu D, An N, Scherer PE, An Z, Lim S. 2023.
Evaluation of the efficacy of a combination of dapagliflozin and lobeglitazone on glucose concentrations and body fat in patients with type 2 diabetes: Location-F study.
Diabetes Obes Metab. 26(3):1114-1119
https://pubmed.ncbi.nlm.nih.gov/38073421/
Lebek S, Caravia XM, Straub LG, Alzhanov D, Tan W, Li H, McAnally JR, Chen K, Xu L, Scherer PE, Liu N, Bassel-Duby R, Olson EN. 2023.
CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model.
J Clin Invest., 134(1):e175164.
https://pubmed.ncbi.nlm.nih.gov/37856214/
Agarwal AK, Tunison K, Vale G, McDonald JG, Li X, Scherer PE, Horton JD and Garg A. 2023.
Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue.
iScience; 26(10):107806.
https://pubmed.ncbi.nlm.nih.gov/37752957/
Maya-Ramos L, Scherer PE and de Lemos JA. 2023.
Small Peptide, Large Implications: Endotrophin in Heart Failure with Preserved Ejection Fraction.
Clin Chem.: 69(8):793-795.
https://pubmed.ncbi.nlm.nih.gov/36738263/
Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Scherer PE, Fang L, Piao HL, Shao M and Gan Z. 2023.
Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes.
Nat Cell Biol., 25(6):848-864
https://pubmed.ncbi.nlm.nih.gov/37217599/
Celen C, Chuang JC, Shen S, Li L, Maggiore G, Jia Y, Luo X, Moore A, Wang Y, Otto JE, Collings CK, Wang Z, Sun X, Nassour I, Park J, Ghaben A, Wang T, Wang SC, Scherer PE, Kadoch C, Zhu H. 2022.
Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
Cell Rep., 41(5):111581
https://pubmed.ncbi.nlm.nih.gov/36323264/
Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. 2022.
Ceramides are early responders in metabolic syndrome development in rhesus monkeys.
Sci Rep.; 12(1):9960
https://pubmed.ncbi.nlm.nih.gov/35705631/
Frankl JA, An Y, Sherwood A, Hao G, Huang FY, Thapa P, Clegg DJ, Sun X, Scherer PE, Öz OK. 2022.
Comparison of BMIPP-SPECT/CT to 18FDG-PET/CT for Imaging Brown or Browning Fat in a Preclinical Model.
Int J Mol Sci.; 23(9):4880
https://pubmed.ncbi.nlm.nih.gov/35563272/
Wang X, Zhang G, Dasgupta S, Niewold EL, Li C, Li Q, Luo X, Tan L, Ferdous A, Lorenzi PL, Rothermel BA, Gillette TG, Adams CM, Scherer PE, Hill JA, Wang ZV. 2022.
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress.
Circ Res.; 131(1):91-105
https://pubmed.ncbi.nlm.nih.gov/35574856/
Zi Z, Zhang Z, Feng Q, Kim C, Wang XD, Scherer PE, Gao J, Levine B, Yu Y. 2022.
Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
Nat Commun.; 13(1):1760
https://pubmed.ncbi.nlm.nih.gov/35365663/
Perez-Frances M, Abate MV, Baronnier D, Scherer PE, Fujitani Y, Thorel F, Herrera PL. 2022.
Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells.
Cell Rep.; 38(7):110377
https://pubmed.ncbi.nlm.nih.gov/35172145/