Publications from Gupta Laboratory


Primary Literature:


Tracking adipogenesis during white adipose tissue development, expansion and regeneration.

Wang QA, Tao C, Gupta RK, Scherer PE.

Nat Med. 2013 Oct;19(10):1338-44. PMID: 23995282


Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice.

Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE.

Diabetologia. 2014 Jun;57(6):1209-18. PMID: 24623101


ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue.

Kim M, Neinast MD, Frank AP, Sun K, Park J, Zehr JA, Vishvanath L, Morselli E, Amelotte M, Palmer BF, Gupta RK, Scherer PE, Clegg DJ.

Mol Metab. 2014 Jun 7;3(6):642-51. PMID: 25161887


Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration.

Ye R, Holland WL, Gordillo R, Wang M, Wang QA, Shao M, Morley TS, Gupta RK, Stahl A, Scherer PE.

Elife. 2014 Oct 23;3. PMID: 25339419


Activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass is associated with gonadal adipose tissues browning.

Neinast MD, Frank AP, Zechner JF, Li Q, Vishvanath L, Palmer BF, Aguirre V, Gupta RK, Clegg DJ.

Mol Metab. 2015 Mar 3;4(5):427-36. PMID: 25973390


Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.

Wang QA, Tao C, Jiang L, Shao M, Ye R, Zhu Y, Gordillo R, Ali A, Lian Y, Holland WL, Gupta RK, Scherer PE.

Nat Cell Biol. 2015 Sep;17(9):1099-111. PMID: 26280538


Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice.

Vishvanath L, MacPherson KA, Hepler C, Wang QA, Shao M, Spurgin SB, Wang MY, Kusminski CM, Morley TS, Gupta RK.

Cell Metab. 2016 Feb 9;23(2):350-9. PMID: 26626462


Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase.

Ye R, Wang QA, Tao C, Vishvanath L, Shao M, McDonald JG, Gupta RK, Scherer PE.

Mol Metab. 2015 Aug 29;4(11):771-8. PMID: 26629402


Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.

Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK.

Cell Metab. 2016 Jun 14;23(6):1167-84. PMID: 27238639


Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE.

Cell Metab. 2016 Sep 13;24(3):420-33. PMID: 27626200


Regeneration of fat cells from myofibroblasts during wound healing.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G.

Science. 2017 Feb 17;355(6326):748-752. PMID: 28059714


PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.

Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL.

Mol Cell. 2017 Jan 19;65(2):260-271. PMID: 28107648


Fetal development of subcutaneous white adipose tissue is dependent on Zfp423.

Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK.

Mol Metab. 2016 Nov 21;6(1):111-124. PMID: 28123942


Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice.

Hepler C, Shao M, Xia JY, Ghaben AL, Pearson MJ, Vishvanath L, Sharma AX, Morley TS, Holland WL, Gupta RK.

Elife. 2017 Jul 19;6. PMID: 28722653


Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression.

Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE.

Diabetes. 2017 Nov;66(11):2789-2799. PMID: 28877911


Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.

Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE.

Diabetologia. 2018 Apr;61(4):932-941. PMID: 29224189


An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.

Zhang F, Hao G, Shao M, Nham K, An Y, Wang Q, Zhu Y, Kusminski CM, Hassan G, Gupta RK, Zhai Q, Sun X, Scherer PE, Oz OK.

Cell Metab. 2018 Jan 9;27(1):252-262.e3. PMID: 29320705


Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE.

J Clin Invest. 2018 Mar 1;128(3):1178-1189. PMID: 29457786


PPARγ and its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.

Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE.

Mol Cell Biol. 2018 Feb 26. PMID: 29483301


De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.

Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK.

Nat Commun. 2018 Mar 1;9(1):890. PMID:29497032


Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.

Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar P, Gupta RK, Horton JD, Hill JA, Scherer PE.

Mol Metab. 2018 Mar 2. PMID: 29551634


Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.

Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED.

Cell Metab. 2018 Apr 5. PMID: 29657031

Invited Review Articles:

Improved methodologies for the study of adipose biology: insights gained and opportunities ahead.

Wang QA, Scherer PE, Gupta RK.

J Lipid Res. 2014 Apr;55(4):605-24. PMID: 24532650



Gupta RK.

Curr Biol. 2014 Oct 20;24(20):R988-93. PMID: 25442852


Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?

Gupta OT, Gupta RK.

Trends Endocrinol Metab. 2015 Oct;26(10):515-23. PMID: 26412153


The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.

Hepler C, Gupta RK.

Mol Cell Endocrinol. 2017 Apr 15;445:95-108. PMID: 27743993


Sorting out adipocyte precursors and their role in physiology and disease.

Hepler C, Vishvanath L, Gupta RK.

Genes Dev. 2017 Jan 15;31(2):127-140. PMID: 28202540


Transcriptional brakes on the road to adipocyte thermogenesis.  

Shao M, Gupta RK.

Biochim Biophys Acta. 2018 May 23. PMID: 29800720

Complete List of Published Work by R. Gupta: