2025 – 2026 Publications
Primary Papers, Reviews and Commentaries from the Lab in 2024-2026:
Pedersen L, Gliniak CM, Dale TM, Zhu Q, Li C, Funcke JB, Crewe C, Luo J, Palluth L, Zhu Y, Scherer PE. 2025.
Induction of Yin Yang 1 (YY1) overexpression in mature adipocytes promotes dysfunctional adipose tissue and systemic insulin resistance in mice.
Metabolism 175 (2026) 156439
https://pubmed.ncbi.nlm.nih.gov/41265559/
https://authors.elsevier.com/a/1m9pR5x4WhpDF
Kim DS, Funcke JB, Chen S, Min K, Onodera T, Kim M, Lin Q, Joung C, Velasco J, Virostek M, Walendzik K, Hiremath C, Marciano DK, Scherer PE. 2025.
ETP-specific-knockout mice reveal endotrophin as a key regulator of kidney fibrosis in ischemia-reperfusion injury models.
Exp Mol Med.; 57(11):2475-2486
https://pubmed.ncbi.nlm.nih.gov/41203998/
Li C, Sun XN, Funcke JB, Vanharanta L, Prasanna X, Gov K, Li Y, Virostek M, Joung C, Joffin N, Kanerva K, Szkalisity A, Kulig W, Straub L, Chen S, Velasco J, Cobb A, La Padula D, Wang MY, Onodera T, Vörös C, Kim DK, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, D Oh DY, Wang ZV, Gordillo R, Goodman JR Wynn RM, Henne WM, VattulaineN I, Han Y, Ikonen E*, Scherer PE*. 2025. *co-corresponding
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.
Science, 390(6773):eadr9755
https://www.science.org/stoken/author-tokens/ST-3029/full
https://pubmed.ncbi.nlm.nih.gov/41196993/
Sun XN, Chen S, Zhao S, Funcke JB, Virostek M, Pedersen L, Li C, Joung C, Lin Q, Li Y, Cobb A, Wang MY, Min K, Maya-Ramos L, Degasperi G, Liu J, Zhang N, An Z, Tomchick DR, Wynn RM, Oh DY, Scherer PE. 2025.
Leptin as a key driver for organ fibrogenesis.
Sci Adv.; 11(43):eady7904
https://pubmed.ncbi.nlm.nih.gov/41124259/
Funcke JB, Scherer PE. 2025.
Much ado about NAA-thing.
Nat Metab. 7(8):1498-1500
https://pubmed.ncbi.nlm.nih.gov/40702166/
Clark AJ, Mendoza Flores B, Saade MC, Vu KQ, Pence IJ, Zhang N, An Z, Bu D, Scherer PE*, Parikh S.*, 2025. *co-corresponding
Acute Kidney Injury is Associated with Elevated Urinary Endotrophin.
Am J Physiol Renal Physiol., in press
https://pubmed.ncbi.nlm.nih.gov/41083270/
Retnakaran R, Bu D, Pu J, Connelly PW, Hanley AJ, Zhang N, An Z, Zinman B, Scherer PE. 2025.
Serum endotrophin relates to blood pressure in young South Asian women but not white women: evidence of ethnic variation in its early vascular implications.
BMC Cardiovasc Disord 2025, 25(1):689
https://pubmed.ncbi.nlm.nih.gov/41023590/
Maya-Ramos L, Scherer PE. 2025.
Adipose Tissue Stress-Related Changes in Mice and Humans with HFpEF.
JACC: Basic to Translational Science, 10(8):101305.
https://authors.elsevier.com/sd/article/S2452-302X(25)00227-X
https://pubmed.ncbi.nlm.nih.gov/40866042/
Onodera T, Kim DS, Wang MY, Virostek M, Chen S, Kipp ZA, Bates EA, Li Y, Crewe C, Li C, Sun XN, Zhang Q, Shao M, Shin J, Kusminski CM, Gordillo R, Gupta RK, Hinds TD, Shimomura I, Scherer PE. 2025.
A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectin.
bioRxiv, 2025.07.12.664095
https://pubmed.ncbi.nlm.nih.gov/40791378/
Cartwright BR*, Scherer PE*. 2025. *co-corresponding
Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity.
Diabetes, 74(10):1710-1719
https://pubmed.ncbi.nlm.nih.gov/40794450/
Funcke JB, Scherer PE. 2025.
Much ado about NAA-thing.
Nat Metabolism, 7(8):1498-1500
http://pubmed.ncbi.nlm.nih.gov/40702166/
Kim DS, Onodera T, Funcke JB, Min K, Zhu Q, Lin Q, Chen S, Joung C, Kim M, Wynn RM, Velasco J, Lee C, Virostek M, Li C, Scherer PE. 2025.
Inhibiting inflammation in adipocytes accelerates mammary tumor development in mice.
J Clin Invest., 135(16):e187202
https://pubmed.ncbi.nlm.nih.gov/40526430/
Le Lay S, Scherer PE. 2025.
Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function.
Cell Rep. 2025 May 22;44(6):115732.
https://pubmed.ncbi.nlm.nih.gov/40408250/
Gliniak CM, Gordillo R, Houm YH, Lin Q, Crewe C, Zhang Z, Field B, Fujikawa T, Virostek M, Zhao S, Zhu Y, Rosen CJ, Horvath TL, Dixit VD, PE Scherer. 2025.
FGF21 Promotes Longevity in Diet-Induced Obesity Through Metabolic Benefits Independent of Growth Suppression.
Cell Metabolism, 37(7):1547-1567
https://authors.elsevier.com/a/1lH795WXUlaYMk
Kruglikov IL, Scherer PE. 2025.
Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis.
Obesity (Silver Spring). 2025 May;33(5):839-850
https://pubmed.ncbi.nlm.nih.gov/40134146/
Straub LG, Funcke JB, Joffin N, Joung C, Al-Ghadban S, Zhao S, Zhu Q, Kruglikov IL, Zhu Y, Langlais PR, Gordillo R, Herbst KL, Scherer PE, 2025.
Defining lipedema’s molecular hallmarks by multi-omics approach for disease prediction in women.
Metabolism 168:156191
https://pubmed.ncbi.nlm.nih.gov/40097137/
https://doi.org/10.1016/j.metabol.2025.156191
Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld A, Campbell JE, Coghlan MP, D’Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. 2025.
Glucose-dependent insulinotropic polypeptide (GIP).
Mol Metab., 95:102118
https://pubmed.ncbi.nlm.nih.gov/40024571/
Kim DK, Funcke JB, Chen S, Min K, Onodera T, Kim M, Velasco J, Virostek M, Walendzik K, Scherer PE. 2025.
ETP-Specific Knockout Mice Reveal Endotrophin as a Key Regulator of Kidney Fibrosis in Ischemia-Reperfusion Injury Models.
bioRxiv [Preprint]. 2025 Feb 26: https://doi.org/10.1101/2025.02.20.639288
https://www.biorxiv.org/content/10.1101/2025.02.20.639288v1
https://pubmed.ncbi.nlm.nih.gov/40060507/
Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. 2025.
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.
Nat Aging, 5(4):576-587
https://pubmed.ncbi.nlm.nih.gov/39972172/
Zhao S, Zhu QZ, Lee WH, Funcke JB, Zhang Z, Wang MY, Lin Q, Field B, Sun X, Li G, Ekane M, Onodera T, Li N, Zhu Y, Kusminski CM, Terry D Hinds TD, Scherer PE. 2025.
The Adiponectin-PPARγ Axis in Hepatic Stellate Cells Regulates Liver Fibrosis.
Cell Reports, 44(1):115165
https://pubmed.ncbi.nlm.nih.gov/39792554/
Yu X, Chen S, Funcke JB, Straub GS, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. 2025.
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.
Cell Metabolism, 37(1):187-204
https://authors.elsevier.com/c/1kDHh5WXUlWkgC
https://pubmed.ncbi.nlm.nih.gov/39642881/
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Collaborative Papers and Reviews 2025-2026:
Funcke JB, Scherer PE, Straub LG. 2026.
Lipedema: a chronic adipose tissue disease.
Trends Mol Med.;32(2):197-198.
https://pubmed.ncbi.nlm.nih.gov/41407589/
Sun XN, Funcke JB, Joung C, Li C, Cobb A, Onodera T, Velasco J, Wang MY, Antonellis PJ, Mazzone C, Senfeld J, Ai M, Scherer PE, Oh DY. 2026.
Neuronal GPR75 deficiency protects against diet-induced obesity in a humanized mouse model.
Sci Adv. 2026 Jan 23;12(4):eady7993
https://pubmed.ncbi.nlm.nih.gov/41576172/
Faria AM, Valerio CM, Barcellos CR, Oliveira RA, Trujilho FR, Baiocchi JMT, Cifarelli V, Scherer PE, Halpern B. 2026.
Unraveling lipedema: comprehensive insights and the path to future discoveries.
NPJ Metab Health Dis. 17;4(1):3.
https://pubmed.ncbi.nlm.nih.gov/41548036/
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. 2025.
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
bioRxiv: 2025.08.04.668533
https://pubmed.ncbi.nlm.nih.gov/40799539/
Abbasi Kasbi N, Stopschinski BE, Polyak AG, Malladi AR, Manouchehri N, Scherer PE, Stuve O. 2025.
Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer’s Disease and Multiple Sclerosis.
Int J Mol Sci.; 27(1):168
https://pubmed.ncbi.nlm.nih.gov/41516046/
Li C, Zhang P, Zhang K, Cook JA, Song W, Virostek M, Slotabec LA, Rouhi N, Hazari M, Adenawoola MI, Liu X, Zhang H, Zhang G, Niewold EL, Li Q, Fang Y, Elhelaly WM, Sun XN, Guo X, Lemoff A, Deng Y, Gillette TG, Li J, Scherer PE, Wang ZV.2026.
Phosphoproteomics Identification of ERK-Dependent Activation of Rps6kb1 in Cardiac Hypertrophy.
JCI Insight., in press
https://pubmed.ncbi.nlm.nih.gov/41505219/
Holst JJ, Schéele C, Scherer PE, Jia W, Segal E, Slavov N, Loos RJF, Vahedi G, Sun L, Babu MM, McCradden MD, Jacobs PG. 2025.
Artificial intelligence in metabolic research.
Nat Metab., 7(11):2183-2186
https://pubmed.ncbi.nlm.nih.gov/41039128/
Griesel BA, Williams K, Ahsan N, Scherer PE, Olson AL, Sparling DP. 2025.
CRISPLD2, a novel insulin-sensitizing adipokine that alters adipocyte size
Obesity (Silver Spring); 33(11):2139-2150
http://doi.org/10.1002/oby.24342
https://pubmed.ncbi.nlm.nih.gov/40855979/
Chen X, Li H, Deng Y, Meng J, Zhao S, Wooton-Kee CR, Gao X, Dong B, Guan D, Wu C, Scherer PE, Zhu Y. 2025.
The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis.
Biomed Pharmacother.; 190:118427
https://pubmed.ncbi.nlm.nih.gov/40774020/
Lingo JJ, Balas MM, Scherer PE, Klein JC. 2025.
The Role of COL6A3 in Tumorigenesis, Metastasis, Diagnosis, and Disease Management.
Cancers, 17(21):3449
https://pubmed.ncbi.nlm.nih.gov/41228242/
Valero-Muñoz M, Cooper HL, Li S, Saw EL, Wilson RM, Kusminski CM, Scherer PE, Sam F., 2025.
Metabolic dysregulation in the heart in obesity-associated HFpEF.
Front Cardiovasc Med., in press
https://pubmed.ncbi.nlm.nih.gov/41079580/
Cheng L, Cheng J, Liang G, Wang X, Ge Y, Liu J, Cai L, Ying H, Wang F, Hu J, Wang Y, Scherer PE, Zhou B, Shao M, Zhang F. 2025.
PDGFRα+DPP4+ Fibroblasts-Macrophage Crosstalk Induces Orbital Fibrosis in Treatment-Resistant Thyroid Eye Disease via the GAS6-AXL Pathway.
Adv Sci (Weinh).29:e11404
https://pubmed.ncbi.nlm.nih.gov/41017741/
Banks AS et al., 2025.
A consensus guide to preclinical indirect calorimetry experiments.
International Indirect Calorimetry Consensus Committee (IICCC)
Nat Metab. 2025 Sep;7(9):1765-1780
https://pubmed.ncbi.nlm.nih.gov/40993210/
Liang Y, Xu Y, Virostek M, Johnson A, Evers B, Deng Y, Meng Y, McDonald JG, Scherer PE, Cui S, Ye J. 2025.
Advanced Alcoholic Liver Disease Driven by a Pro-Ferroptotic Diet.
J Lipid Res., in press
https://pubmed.ncbi.nlm.nih.gov/40945609/
https://authors.elsevier.com/sd/article/S0022227525001609
Chen X, Li H, Deng Y, Meng J, Zhao S, Wooton-Kee CR, Gao X, Dong B, Guan D, Wu C, Scherer PE, Zhu Y. 2025.
The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis.
Biomed Pharmacother;190:118427
https://pubmed.ncbi.nlm.nih.gov/40774020/
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. 2025.
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
bioRxiv [Preprint]
https://pubmed.ncbi.nlm.nih.gov/40799539/
Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. 2025.
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.
Nat Aging.;5(4):576-587.
https://pubmed.ncbi.nlm.nih.gov/39972172/
Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld AL, Campbell JE, Coghlan MP, D’Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. 2025.
Glucose-dependent insulinotropic polypeptide (GIP).
Mol Metab.;95:102118
https://pubmed.ncbi.nlm.nih.gov/40024571/
Chen X, Li H, Deng Y, Meng J, Zhao S, Wooton-Kee CR, Gao X, Dong B, Guan D, Wu C, Scherer PE, Zhu Y. 2025.
The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis
bioRxiv [Preprint]: 2025.05.19.654778
https://pubmed.ncbi.nlm.nih.gov/40475534/
Alba DL, Choi MK, Abdellatif A, Brown Mayfield S, Pham TAT, Berrios D, Rodriguez A, Ewing M, Figueroa T, Gonzalez-Vargas J, Zhang N, An Z, Bu D, Deeks SG, Scherer PE, Hunt PW, Koliwad SK. 2025.
A Distinct Form of Subcutaneous Fat Fibrosis Predicts Insulin Resistance in People with HIV.
medRxiv [Preprint]. 2025:2025.05.13.25327547
https://pubmed.ncbi.nlm.nih.gov/40463535/
Giugni F, Maya-Ramos L, Yang Y, Arthur V, Claggett B, Gillette T, Scherer PE,
Hill JA, de Lemos JA, Hoogeveen R, Ballantyne CM, Ndumele CE, Yu B, Shah AM. 2025.
PLASMA ENDOTROPHIN IS ASSOCIATED WITH RISK OF HFPEF BUT NOT HFrEF: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
JACC, Volume 85, Issue 12, Suppl A
https://www.sciencedirect.com/science/article/pii/S0735109725020078?via%3Dihub
Liu W, Mao R, Nga Le TH, West G, Varadharajan V, Banerjee R, Doyon G, Mukherjee P, Nguyen QT, Mulya A, Rennison JH, Gordon IO, Cruise M, Hu S, Czarnecki D, Plesec T, Chandra J, Banerjee S, Wang J, Massey WJ, Goren I, Lin SN, Kurada S, Cohen BL, Qazi T, Holubar SD, Lipman J, Kanters A, Gliniak CM, Scherer PE, Chen MH, Siegmund B, Ivanov AI, Fiocchi C, Van Wagoner DR, Brown JM, Rieder F. 2025.
Creeping Fat-Derived Free Fatty Acids Induce Hyperplasia of Intestinal Muscularis Propria Muscle Cells: A Novel Link Between Fat and Intestinal Stricture Formation in Crohn’s Disease.
Gastroenterology;168(3):508-524
https://pubmed.ncbi.nlm.nih.gov/39522890/
Samms RJ, Kusminski CM. 2025.
A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity.
Annu Rev Physiol; 87(1):279-299
https://pubmed.ncbi.nlm.nih.gov/39546586/