2018/2019 Publications               

 

Primary Papers, Reviews and Commentaries from the Lab in 2018-2019:

 

An A, Crewe C, Wernstedt Asterholm I, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, Scherer PE. 2019.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity.

Nat Metabolism, in press

 

Scherer PE. 2019.

Mechanisms Underlying the Metabolic Syndrome

Series edited by Philipp E. Scherer

  1. Clin Inv., 129(10)

https://www.jci.org/review_series/107

 

Wang QA, Scherer PE. 2019.

Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution

Journal of Mammary Gland Biology and Neoplasia, 24(3):207-212.

http://www.ncbi.nlm.nih.gov/pubmed/31512027

 

Kruglikov IL, Zhang Z, Scherer PE. 2019.

Caveolin-1 in Skin Aging: From Innocent Bystander to Major Contributor

Ageing Research Reviews, 55:100959

http://doi.org/10.1016/j.arr.2019.100959

 

Shao M, Wang QA, Song A, Vishvanath L, Busbuso NC, Scherer PE*, Gupta RK*. 2019.  *co-correspong authors

Cellular Origins of Beige Fat Cells Revisited.

Diabetes. 2019 Oct;68(10):1874-1885

http://www.ncbi.nlm.nih.gov/pubmed/31540940

 

Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An A, Zhu Yi, Ghaben A, Wang M-Y, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. 2019.

Dermal adipose tissue has high plasticity and undergoes reversible de-differentiation in mice.

  1. Clin Inv., in press

http://www.ncbi.nlm.nih.gov/pubmed/31503545

 

Stern JH, Smith GI, Chen S, Unger RH, Klein S, Scherer PE. 2019.

Obesity dysregulates fasting-induced changes in glucagon secretion

J Endocrinol., in press

http://dx.doi.org/10.1530/JOE-19-0201

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/31454790

 

Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GW, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE. 2019.

Partial Leptin Reduction as an Effective Weight Loss Strategy

Cell Metabolism, 30; (4)706-719

http://www.ncbi.nlm.nih.gov/pubmed/31495688

https://authors.elsevier.com/a/1Zq6d5WXUlEpAQ

 

Kusminski CM, Scherer PE. 2019.

Lowering ceramides to overcome diabetes

Science, 365(6451):319-320.

http://www.ncbi.nlm.nih.gov/pubmed/31346052

Reprint: http://science.sciencemag.org/cgi/rapidpdf/365/6451/319?ijkey=7iHpher3qVBIg&keytype=ref&siteid=sci

 

Crewe C, Zhu Y, Paschoal VA, Joffin N, Ghaben AL, Gordillo R, Oh DY, Liang G, Horton JD, Scherer PE. 2019.

SREBP-regulated Adipocyte Lipogenesis is Dependent on Substrate Availability and Redox Modulation of mTORC1

JCI Insight, 5. pii: 129397. doi: 10.1172/jci.insight.129397

http://www.ncbi.nlm.nih.gov/pubmed/31310592

 

Funcke JB, Scherer PE. 2019

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

  1. Lipid Res., 60(10):1648-1684

http://www.jlr.org/content/early/2019/06/17/jlr.R094060.full.pdf+html

 

Gliniak CM, Scherer PE. 2019

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood 

J Clin Inv., 130:2198-2200

http://www.ncbi.nlm.nih.gov/pubmed/31081800

 

Kruglikov IL, Scherer PE. 2019.

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

npj Aging and Mechanisms of Disease, 4:9 doi: 10.1038/s41536-019-0071-x

http://rdcu.be/byHdt

http://www.ncbi.nlm.nih.gov/pubmed/31044089

 

Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu X-Z, Lønning PE, Halberg N, Rios A, Chang Y, Gonzalez A, Zhang N, An Z, Scherer PE. 2019.

Human Endotrophin as a Driver of Malignant Tumor Growth

JCI Insight, ;4(9):e125094

http://www.ncbi.nlm.nih.gov/pubmed/30896449

 

Straub LG, Scherer PE. 2019.

Metabolic Messengers: Adiponectin

Nature Metabolism, 1, 334–339

http://rdcu.be/bq3NN

 

Ye R, Onodera T, Scherer PE. 2019.

Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes

J Endocr Soc., 3(3):617-631

http://www.ncbi.nlm.nih.gov/pubmed/30834357

 

Ye R, Onodera T, Blanchard P-G, Kusminski CM, Esser V, Brekken RA, Scherer PE. 2019.

β1 syntrophin supports autophagy initiation and protects against cerulein-induced acute pancreatitis.

Am J Pathol., 189(4):813-825

http://www.ncbi.nlm.nih.gov/pubmed/30653956

 

Kruglikov IL, Scherer PE. 2019.

Caveolin-1 as a Pathophysiological Factor and Target in Psoriasis

npj Aging and Mechanisms of Disease, 5:4. doi: 10.1038/s41514-019-0034-x.

https://rdcu.be/bkfWC

http://www.ncbi.nlm.nih.gov/pubmed/31044089

 

Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. 2018.

An Endothelial to Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Cell, 175(3):695-708

http://www.ncbi.nlm.nih.gov/pubmed/30293865

 

Kruglikov IL, Zhang Z, Scherer PE. 2018.

The Role of Immature and Mature Adipocytes in Hair Cycling

Trends Endocrinol Metab., 30(2):93-105

http://www.ncbi.nlm.nih.gov/pubmed/30558832

 

Scherer PE. 2018.

The many secret lives of adipocytes: implications for diabetes

Diabetologia, 62(2):223-232.

http://www.ncbi.nlm.nih.gov/pubmed/30465066

 

Joffin N, Scherer PE. 2018.

Reducing oxygen consumption in fat

Nature, 564(7734):47-48

http://www.ncbi.nlm.nih.gov/pubmed/30510226

 

Ghaben AL, Scherer PE. 2018.

Adipogenesis and Metabolic Health

Nature Reviews Molecular Cell Biology, in press

http://www.ncbi.nlm.nih.gov/pubmed/30610207

 

Kruglikov IL, Scherer PE. 2018.

Skin aging as a mechanical phenomenon: The main weak links.

Nutr Healthy Aging; 4(4):291-307

http://www.ncbi.nlm.nih.gov/pubmed/29951590

 

Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer P.E. 2018.

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors During Lactation.      

Cell Metabolism, 28(2):282-288

http://www.ncbi.nlm.nih.gov/pubmed/29909970

 

Kusminski CM, Scherer PE. 2018.

New zoning laws enforced by glucagon.

Proc Natl Acad Sci U S A., 115(17):4308-4310

http://www.ncbi.nlm.nih.gov/pubmed/29632201

 

Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar I, Gupta RK, Horton JD, Hill JA, Scherer PE. 2018.

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Molecular Metabolism, 11:1-17

http://www.ncbi.nlm.nih.gov/pubmed/29551634

 

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. 2018.

Intracellular lipid metabolism impairs β-cell compensation during diet-induced obesity

  1. Clin. Inv., 128(3):1178-1189

http://www.ncbi.nlm.nih.gov/pubmed/29457786

 

Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. 2018.

PPARγ and its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Mol. Cell Biol., 30;38(10)

http://www.ncbi.nlm.nih.gov/pubmed/29483301

 

Zhu Y, Kruglikov IL, Akgul Y, Scherer PE. 2018.

Hyaluronan in Adipogenesis, Adipose Tissue Physiology and Systemic Metabolism

Matrix Biology, 78-79:284-291

http://www.ncbi.nlm.nih.gov/pubmed/29458140

 

Zhang Z, Scherer PE. 2018.

The dysfunctional adipocyte — a cancer cell’s best friend

Nat Rev Endocrinol., 14(3):132-134

http://www.ncbi.nlm.nih.gov/pubmed/29302078

 

Zhu Q, Scherer PE. 2018.

Immunologic and endocrine functions of adipose tissue: implications for kidney disease.

Nat Rev Nephrol., 14(2):105-120

http://www.ncbi.nlm.nih.gov/pubmed/29199276

 

Zhang F, Hao G, Shao M, Hassan G, An YA, Wang Q, Zhu Y, Kusminski CM, Nham K, Gupta RK, Zhai Q, Sun X, Scherer PE*, Oz OK*. 2018.

An Adipose Tissue Atlas: An Image Guided Identification of Human-like BAT and Beige Depots in Rodents.

Cell Metabolism, 27(1):252-262.

http://www.ncbi.nlm.nih.gov/pubmed/29320705

 

Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. 2018.

Acute Loss of Adipose Tissue-Derived Adiponectin Triggers Immediate Metabolic Deterioration.

Diabetologia, 61(4):932-941

http://www.ncbi.nlm.nih.gov/pubmed/29224189

____________________________________________________________________

 

Collaborative Papers and Reviews 2018-2019:

 

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Liu Y, Zhu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. 2019.

  1. Clin Inv., in press

http://www.ncbi.nlm.nih.gov/pubmed/31573981

 

Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights

Frankl J , Sherwood A, Clegg DJ, Scherer PE, Öz OK. 2019.

Int J Mol Sci., 5;20(21)

http://www.ncbi.nlm.nih.gov/pubmed/31694216

 

Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW. 2019.

Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.

Kidney Int., in press

http://www.ncbi.nlm.nih.gov/pubmed/31601454

 

Caron A, Reynolds RP, Castorena CM, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK. 2019.

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.

Mol Metab., 27:11-21

http://www.ncbi.nlm.nih.gov/pubmed/31279640

Reprint: https://doi.org/10.1016/j.molmet.2019.06.019

 

Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV.

Spliced X-Box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.

Circulation, 140(7):566-579

https://www.ncbi.nlm.nih.gov/pubmed/31177839

 

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O’Neal WK, Boucher RC. 2019.

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia.

Am J Respir Crit Care Med., 200(2):220-234

http://www.ncbi.nlm.nih.gov/pubmed/30973754

 

Furman JL, Soyombo A, Czysz AH, Jha MK, Carmody TJ, Mason BL, Scherer PE, Trivedi MH. 2019.

Adiponectin Moderates Antidepressant Treatment Outcome in the Combining Medications to Enhance Depression Outcomes Randomized Clinical Trial.

Pers Med Psychiatry, Aug-Sep; 9-10: 1–7

http://www.ncbi.nlm.nih.gov/pubmed/30859144

 

Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Stern JH, Campbell JE, Scherer PE, Drucker DJ. 2019.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Mol. Metab., 22: 37–48

http://www.ncbi.nlm.nih.gov/pubmed/30772257

 

Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Chakraborty A, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. 2019.

VEGF-D overexpression and lymphatic expansion in murine adipose tissue improves metabolism in obesity.

Am J Pathol., 189(4):924-939

http://www.ncbi.nlm.nih.gov/pubmed/30878136

 

Peri-Okonny P, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, CastorenaCM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W. 2019.

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Circulation, 139(11):1422-1434

http://www.ncbi.nlm.nih.gov/pubmed/30612451

 

Stern JH, Arriaga Y, Gupta A, Verma U, Karri S, Syed S, Khosama L, Mansour J, Meyer J, Scherer PE, Beg MS. 2019.

Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Pancreas, 48(1):e1-e3

http://www.ncbi.nlm.nih.gov/pubmed/30531245

 

Sun F, You J, Lei Y, Sun L, Garza J, Zhang D, Guo M, Scherer PE, Lodge D, Lu XY. 2019.

Adiponectin, via AdipoR1, modulates ventral tegmental area dopamine neuronal activity and anxiety-related behavior.

Mol. Psychiatry, 24(1): 126–144.

http://www.ncbi.nlm.nih.gov/pubmed/29988086

 

Lee C, Kim M, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J. 2018.

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.

J Pathol., 247(1):99-109

http://www.ncbi.nlm.nih.gov/pubmed/30246318

 

Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK. 2018.

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Mol Metab., 14:121-129

http://www.ncbi.nlm.nih.gov/pubmed/29884546

 

Neeland IJ, Singh S, McGuire DK, Vega GL, Roddy T, Reilly DF, Castro-Perez J, Kozlitina J, Scherer PE. 2018.

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Diabetologia, 61(12):2570-2579

http://www.ncbi.nlm.nih.gov/pubmed/30159588

 

Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin Y, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. 2018.

HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.

JCI Insight, 3(15):e120159

http://www.ncbi.nlm.nih.gov/pubmed/30089714

 

Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA. 2018.

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Mol Metab., 16:139-149

http://www.ncbi.nlm.nih.gov/pubmed/29935921

 

Akgul Y, Constantine R, Bartels M, Scherer P, Davis K, Kenkel JM. 2018.

Utility of Adipocyte Fractions in Fat Grafting in an Athymic Rat Model.

Aesthet Surg J., 38(12):1363-1373

http://www.ncbi.nlm.nih.gov/pubmed/29722790

 

Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH. 2018.

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Mol Metab., 11:212-217

http://www.ncbi.nlm.nih.gov/pubmed/29650351

 

Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M. 2018.

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress and inflammation in non-alcoholic steatohepatitis.

Diabetes Care, 41(6):1235-1243

http://www.ncbi.nlm.nih.gov/pubmed/29602794

 

Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV. 2018.

Cell Death Differ., 25(12):2181-2194

http://www.ncbi.nlm.nih.gov/pubmed/29666470

 

Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. 2018.

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Nat Med., 24(5):617-627

http://www.ncbi.nlm.nih.gov/pubmed/29662201