2020/2021 Publications               

 

Primary Papers, Reviews and Commentaries from the Lab in 2020-2021:

 

Crewe C, Funcke JB, Li S, Joffin N, Gliniak CM, Ghaben AL, An YA, Sadek HA, Gordillo R, Akgul Y, Chen S, Samovski D, Fischer-Posovszky P, Kusminski CM, Klein S and Scherer PE. 2021.

Extracellular vesicle-Based Interorgan Transport of Mitochondria from Energetically Stressed Adipocytes.

Cell Met., 33(9):1853-1868.

https://authors.elsevier.com/a/1dcL3_ZG9ULL0D

https://pubmed.ncbi.nlm.nih.gov/34418352/

 

Zhu Y, Li N, Huang M, Bartels M, Dogné S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang Y, Gliniak CM, Gordillo R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE. 2021.

Adipose Tissue Hyaluronan Production Improves Systemic Glucose Homeostasis and Primes Adipocytes for CL 316,243-stimulated Lipolysis.

Nat. Comm., 12(1):4829

https://rdcu.be/ctL2s

https://pubmed.ncbi.nlm.nih.gov/34376643/

 

Zhang Z, Funcke JB,, Zi Z, Zhao S, Straub L, Zhu Yi, Zhu Q,, Crewe C, An YA, Chen S, Li N, Wang MY, Gaben AL, Lee C, Gautron L, Engelking  LJ, Raj P., Deng Y, Gordillo R, Christine M. Kusminski CM, Scherer PE. 2021.

Adipocyte iron levels impinge on a fat-gut cross-talk to regulate intestinal lipid absorption and mediate protection from obesity.

Cell Metabolism, 33(8):1624-1639

https://pubmed.ncbi.nlm.nih.gov/34174197/

https://authors.elsevier.com/a/1dIf25WXUlLHpM

 

Scherer PE, Gupta OT. 2021.

Endotrophin: Nominated for Best Supporting Actor in the Fibro-Inflammatory Saga.

EBioMedicine, 69:103447

https://pubmed.ncbi.nlm.nih.gov/34153872/

https://authors.elsevier.com/sd/article/S2352396421002401

 

Li N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang MY, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE. 2021

Adiponectin preserves metabolic fitness during aging.

Elife, 10:e65108

https://pubmed.ncbi.nlm.nih.gov/?term=scherer+pe&sort=pubdate&size=200

 

An YA, Chen S, Deng Y, Wang ZV, Funcke JB, Shah M, Shan B, Gordillo R, Yoshino J, Klein S, Kusminski CM, Scherer PE. 2021.

The mitochondrial dicarboxylate carrier (mDIC) prevents liver lipotoxicity through inhibiting white adipocyte lipolysis.

J Hepatol., 75, 387-399

https://pubmed.ncbi.nlm.nih.gov/33746082/

https://authors.elsevier.com/a/1d0vicOnAJ8mG

 

Onodera T, Scherer PE. 2021.

From Friend to Foe: Proapoptotic action of nuclear ARC in diabetes.

Dev Cell, 56(6):717-718

https://pubmed.ncbi.nlm.nih.gov/33756115/

 

Kruglikov IL and Scherer PE. 2021.

Pre-existing and Inducible Endotoxemia as Crucial Contributors to Severity of COVID-19 Outcomes.

PLoS Pathog., 17(2):e1009306

https://pubmed.ncbi.nlm.nih.gov/33600486/

 

Hagström H, Bu D, Nasr P, Ekstedt M, Hegmar H, Kechagias S, Zhang N, An Z, Stål P, Scherer PE. 2021.

Serum Levels of Endotrophin are Associated with Nonalcoholic Steatohepatitis

Scand J Gastroenterol., 56(4):437-442

https://pubmed.ncbi.nlm.nih.gov/33556256/

 

Crewe C, Scherer PE. 2021.

Intercellular and interorgan crosstalk through adipocyte extracellular vesicles

Rev Endocr Metab Disord., in press

https://link.springer.com/article/10.1007/s11154-020-09625-x

https://pubmed.ncbi.nlm.nih.gov/33447986/

 

Zhao S, Kusminski CM and Scherer PE. 2021.

Adiponectin, Leptin and Cardiovascular Disorders

Circ Res., 128(1):136-149

http://pubmed.ncbi.nlm.nih.gov/33411633/

 

Joffin N, Paschoal VA, Gliniak CM, Crewe C, Elnwasany A, Szweda LI, Zhang Q, Hepler C, Kusminski CM, Gordillo R, Oh DY, Gupta RK, Scherer PE. 2021.

Mitochondrial metabolism as a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.              

Cell Stem Cell, 28(4):702-717

https://pubmed.ncbi.nlm.nih.gov/33539722/

Commentary

Cell Stem Cell, 28(4):589-591

https://pubmed.ncbi.nlm.nih.gov/33798417/

 

Scherer PE, Newgard CB. 2020.

A tribute to Roger H. Unger (1924-2020).

J Clin Invest. 130(12):6191-6193.

http://pubmed.ncbi.nlm.nih.gov/33258805/

 

Field BC, Gordillo R, Scherer PE. 2020.

The Role of Ceramides in Diabetes and Cardiovascular Disease

Regulation of Ceramides by Adipokines

Front Endocrinol, 11:569250

http://pubmed.ncbi.nlm.nih.gov/33133017/

 

Kim M, Lee C, Seo DY, Horton JD, Park JY, Scherer PE. 2020.

The Impact of Endotrophin on the Progression of Chronic Liver Disease

Experimental & Molecular Medicine, 52(10):1766-1776

http://pubmed.ncbi.nlm.nih.gov/33110211/

 

Kruglikov IL, Shah M, Scherer PE. 2020.

Obesity and diabetes as comorbidities for COVID-19:

Underlying Mechanisms and the Role of Viral-Bacterial Interactions.

Elife, 9:e61330

http://pubmed.ncbi.nlm.nih.gov/32930095/

 

Zhang Z, Kruglikov IL, Zhao S, Zi Z, Gliniak CM, Li N, Wang MY, Zhu Q, Kusminski CM, Scherer PE. 2020.

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts.

Exp Dermatol, 30(1):102-111

http://pubmed.ncbi.nlm.nih.gov/32866299/

 

An YA, Scherer PE. 2020.

Mouse Adipose Tissue Protein Extraction.

Bio Protoc.; 10(11):e3631.

https://pubmed.ncbi.nlm.nih.gov/33659303/

 

Gliniak CM, PE Scherer. 2020.

PHOSPHO1 puts the breaks on thermogenesis in brown adipocytes.

Proc Natl Acad Sci USA., 117(29):16726-16728.

http://pubmed.ncbi.nlm.nih.gov/32641502/

 

Kruglikov IL, Joffin N, PE Scherer. 2020.

The MMP-14/Caveolin Axis and Its Potential Relevance for Lipedema

Nat Rev Endocrinol., 16(11):669-674.

https://rdcu.be/ctXe0

http://pubmed.ncbi.nlm.nih.gov/32792644/

 

Zhu Q, An YA, Kim M, Zhang Z, Zhao S, Zhu Y, Wernstedt Asterholm I, Kusminski CM, and PE Scherer. 2020.

Suppressing Adipocyte Inflammation Promotes Insulin Resistance in Mice

Mol Metabolism, 39:101010

https://doi.org/10.1016/j.molmet.2020.101010

http://pubmed.ncbi.nlm.nih.gov/32408016

 

Kruglikov IL, and PE Scherer. 2020.

The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections.

Obesity, 28(7):1187-1190

http://www.ncbi.nlm.nih.gov/pubmed/32339391

 

Zhao S, Li N, Zhu Y, Straub L, Zhang Z, Wang MY, Qingzhang Zhu Q, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Partial leptin deficiency confers resistance to diet-induced obesity in mice.

Mol Metabolism, 37:100995

http://www.ncbi.nlm.nih.gov/pubmed/32289482

https://doi.org/10.1016/j.molmet.2020.100995

 

Zhao S, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Leptin: Less is More

Diabetes, 69:823–829

http://www.ncbi.nlm.nih.gov/pubmed/32312898

 

Voices: The Future of Metabolism. 2020.

Cell Metabolism, 31, 1, 3-5

http://www.sciencedirect.com/science/article/pii/S155041311930676X?via%3Dihub

 

An A, Crewe C, Wernstedt Asterholm I, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, and PE Scherer. 2019.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Nat Metabolism, VOL 1 , 1243–1257

http://rdcu.be/bYXYF

http://www.ncbi.nlm.nih.gov/pubmed/31984308

 

Kruglikov IL, and PE Scherer. 2020.

Caveolin as a Universal Target in Dermatology

Int J Mol Sci, 20;21(1)

http://www.ncbi.nlm.nih.gov/pubmed/31877626

http://www.mdpi.com/1422-0067/21/1/80/pdf

 

Kusminski CM, Ghaben AL, Morley TS, Samms RJ, Adams AC, An Y, Johnson JA,

Joffin N, Onodera T, Crewe C, Holland WL, Gordillo R and PE Scherer. 2020.

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-cell Hyperplasia

Diabetes, 69(3):313-330

http://www.ncbi.nlm.nih.gov/pubmed/31882562

___________________________________________________________________

 

Collaborative Papers and Reviews 2020-2021:

 

Wang S, Zhu Q, Liang G, Franks T, Boucher M, Bence KK, Lu M, Castorena CM, Zhao S, Elmquist JK, Scherer PE, Horton JD. 2021

Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.

J Clin Invest., in press

https://pubmed.ncbi.nlm.nih.gov/34499619/

 

Onodera T, Ghazvini Zadeh E, Xu P, Gordillo R, Guo Z, Joffin N, Yu B, Scherer PE, Li WH. 2021.

PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high fat diet conditions.

J Lipid Res., in press

https://pubmed.ncbi.nlm.nih.gov/34214600/

https://doi.org/10.1016/j.jlr.2021.100095

 

Jang AY, Scherer PE, Kim JY, Lim S, Koh KK, 2021.

Adiponectin and cardiometabolic trait and mortality: where do we go?

Cardiovasc Res, in press

https://pubmed.ncbi.nlm.nih.gov/34117867/

 

Li Q, Li C, Elnwasany A, Sharma G, An YA, Zhang G, Elhelaly WM, Lin J, Gong Y, Chen G, Wang MH, Zhao S, Dai C, Smart CD, Liu J, Luo X, Deng Y, Tan L, Lv SJ, Davidson SM, Locasale JW, Lorenzi PL, Malloy CR, Gillette TG, Vander Heiden MG, Scherer PE, Szweda LI, Fu G, Wang ZV. 2021.

PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Circulation, 144(9):712-727

https://pubmed.ncbi.nlm.nih.gov/34102853/

 

Cannavino J, Shao M, An YA, Bezprozvannaya S, Chen S, Kim J, Xu L, McAnally JR, Scherer PE, Liu N, Gupta RK, Bassel-Duby R, Olson EN. 2021.

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A

Proc Natl Acad Sci USA, 118(23):e2104650118

https://pubmed.ncbi.nlm.nih.gov/34088848/

https://www.pnas.org/content/118/23/e2104650118

 

Yang R, Lee EE, Kim J, Choi JH, Kolitz E, Chen Y, Crewe C, Salisbury NJH, Scherer PE, Cockerell C, Smith TR, Rosen L, Verlinden L, Galloway DA, Buck CB, Feltkamp MC, Sullivan CS, Wang RC. 2021.

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.

PLoS Pathog; 17(5):e1009582

https://pubmed.ncbi.nlm.nih.gov/33999949/

 

Lizardo K, Ayyappan JP, Oswal N, Weiss LM, Scherer PE, Nagajyothi JF. 2021.

Fat tissue regulates the pathogenesis and severity of cardiomyopathy in murine chagas disease. 2021.

PLoS Negl Trop Dis.;15(4):e0008964

https://pubmed.ncbi.nlm.nih.gov/33826636/

 

Chen S, Huang ZJ, Kidd H, Kim M, Suh EH, Xie S, Ghazvini Zadeh EH, Xu Y, Sherry AD, Scherer PE, Li WH. 2021.

In Vivo ZIMIR Imaging of Mouse Pancreatic Islet Cells Shows Oscillatory Insulin Secretion.

Front. Endocrinol., 12:613964

https://pubmed.ncbi.nlm.nih.gov/33767668/

 

Wang MY, Dean ED, Quittner-Strom E, Zhu Y, Chowdhury KH, Zhang Z, Zhao S, Li N, Ye R, Lee Y, Zhang Y, Chen S, Yu X, Leonard DC, Poffenberger G, Von Deylen A, McCorkle SK, Schlegel A, Sloop KW, Efanov AM, Gimeno RE, Scherer PE, Powers AC, Unger RH and WL Holland. 2021.

Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets.

Proc Natl Acad Sci U S A., 118(9):e2022142118

https://pubmed.ncbi.nlm.nih.gov/33619103/

 

Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G and RJ Davis. 2021.

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21.

Genes Dev., 35(1-2):133-146

http://pubmed.ncbi.nlm.nih.gov/33334822/

 

Apostolopoulou M, Gordillo R, Gancheva S, Strassburger K, Herder C, Esposito I, Schlensak M, Scherer PE, Roden M. 2020.

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans.

BMJ Open Diabetes Res Care.;8(2):e001860 http://pubmed.ncbi.nlm.nih.gov/33219119/

 

Zhang Z, Gallagher T, Scherer PE, Beutler B. 2020.

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Proc Natl Acad Sci U S A, 117(21):11829-11835

http://pubmed.ncbi.nlm.nih.gov/32381739/

 

Pedersen L, Panahandeh P, Siraji MI, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. 2020.

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer.

Cancer Res., 80(11):2163-2174

http://www.ncbi.nlm.nih.gov/pubmed/32291319

 

Li X, Zhao Y, Chen C, Yang L, Lee HH, Wang Z, Zhang N, Kolonin MG, An Z, Ge X, Scherer PE, Sun K. 2020.

The critical role of MMP14 in adipose tissue remodeling during obesity.

Mol Cell Biol., 30;40(8). pii: e00564-19

http://www.ncbi.nlm.nih.gov/pubmed/31988105

 

Zaki P, Domingues ELBC, Amjad FM, Narde MB, Gonçalves KR, Viana ML, de Paula H, de Lima WG, Huang H, Bahia MT, Scherer PE, Dos Santos FM, Weiss LM, Tanowitz HB. 2020.

The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection.

Parasitol Res., 119(6):1845

http://www.ncbi.nlm.nih.gov/pubmed/32206887

 

Williams T, Guerrero-Ros I, Ma Y, Matos Dos Santos F, Scherer PE, Gordillo R, Horta A, Macian F, Weiss LM, Huang H. 2020.

Induction of effective immunity against Trypanosoma cruzi.

Infect Immun., 23;88(4)

http://www.ncbi.nlm.nih.gov/pubmed/31907197

 

Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. 2020.

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.

FASEB J, 34(2):2087-2104

http://www.ncbi.nlm.nih.gov/pubmed/31907991

 

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Liu Y, Zhu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. 2020.

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

  1. Clin Inv., 130(1):247-257

http://www.ncbi.nlm.nih.gov/pubmed/31573981