2018/2019 Publications               


Primary Papers, Reviews and Commentaries from the Lab in 2018-2019:


An A, Crewe C, Wernstedt Asterholm I, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, Scherer PE. 2019.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity.

Nat Metabolism, in press


Scherer PE. 2019.

Mechanisms Underlying the Metabolic Syndrome

Series edited by Philipp E. Scherer

  1. Clin Inv., 129(10)



Wang QA, Scherer PE. 2019.

Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution

Journal of Mammary Gland Biology and Neoplasia, 24(3):207-212.



Kruglikov IL, Zhang Z, Scherer PE. 2019.

Caveolin-1 in Skin Aging: From Innocent Bystander to Major Contributor

Ageing Research Reviews, 55:100959



Shao M, Wang QA, Song A, Vishvanath L, Busbuso NC, Scherer PE*, Gupta RK*. 2019.  *co-correspong authors

Cellular Origins of Beige Fat Cells Revisited.

Diabetes. 2019 Oct;68(10):1874-1885



Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An A, Zhu Yi, Ghaben A, Wang M-Y, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. 2019.

Dermal adipose tissue has high plasticity and undergoes reversible de-differentiation in mice.

  1. Clin Inv., in press



Stern JH, Smith GI, Chen S, Unger RH, Klein S, Scherer PE. 2019.

Obesity dysregulates fasting-induced changes in glucagon secretion

J Endocrinol., in press


Reprint: http://www.ncbi.nlm.nih.gov/pubmed/31454790


Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GW, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE. 2019.

Partial Leptin Reduction as an Effective Weight Loss Strategy

Cell Metabolism, 30; (4)706-719




Kusminski CM, Scherer PE. 2019.

Lowering ceramides to overcome diabetes

Science, 365(6451):319-320.


Reprint: http://science.sciencemag.org/cgi/rapidpdf/365/6451/319?ijkey=7iHpher3qVBIg&keytype=ref&siteid=sci


Crewe C, Zhu Y, Paschoal VA, Joffin N, Ghaben AL, Gordillo R, Oh DY, Liang G, Horton JD, Scherer PE. 2019.

SREBP-regulated Adipocyte Lipogenesis is Dependent on Substrate Availability and Redox Modulation of mTORC1

JCI Insight, 5. pii: 129397. doi: 10.1172/jci.insight.129397



Funcke JB, Scherer PE. 2019

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

  1. Lipid Res., 60(10):1648-1684



Gliniak CM, Scherer PE. 2019

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood 

J Clin Inv., 130:2198-2200



Kruglikov IL, Scherer PE. 2019.

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

npj Aging and Mechanisms of Disease, 4:9 doi: 10.1038/s41536-019-0071-x




Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu X-Z, Lønning PE, Halberg N, Rios A, Chang Y, Gonzalez A, Zhang N, An Z, Scherer PE. 2019.

Human Endotrophin as a Driver of Malignant Tumor Growth

JCI Insight, ;4(9):e125094



Straub LG, Scherer PE. 2019.

Metabolic Messengers: Adiponectin

Nature Metabolism, 1, 334–339



Ye R, Onodera T, Scherer PE. 2019.

Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes

J Endocr Soc., 3(3):617-631



Ye R, Onodera T, Blanchard P-G, Kusminski CM, Esser V, Brekken RA, Scherer PE. 2019.

β1 syntrophin supports autophagy initiation and protects against cerulein-induced acute pancreatitis.

Am J Pathol., 189(4):813-825



Kruglikov IL, Scherer PE. 2019.

Caveolin-1 as a Pathophysiological Factor and Target in Psoriasis

npj Aging and Mechanisms of Disease, 5:4. doi: 10.1038/s41514-019-0034-x.




Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE. 2018.

An Endothelial to Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Cell, 175(3):695-708



Kruglikov IL, Zhang Z, Scherer PE. 2018.

The Role of Immature and Mature Adipocytes in Hair Cycling

Trends Endocrinol Metab., 30(2):93-105



Scherer PE. 2018.

The many secret lives of adipocytes: implications for diabetes

Diabetologia, 62(2):223-232.



Joffin N, Scherer PE. 2018.

Reducing oxygen consumption in fat

Nature, 564(7734):47-48



Ghaben AL, Scherer PE. 2018.

Adipogenesis and Metabolic Health

Nature Reviews Molecular Cell Biology, in press



Kruglikov IL, Scherer PE. 2018.

Skin aging as a mechanical phenomenon: The main weak links.

Nutr Healthy Aging; 4(4):291-307



Wang QA, Song A, Chen W, Schwalie PC, Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, Gupta RK, Deplancke B, Scherer P.E. 2018.

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors During Lactation.      

Cell Metabolism, 28(2):282-288



Kusminski CM, Scherer PE. 2018.

New zoning laws enforced by glucagon.

Proc Natl Acad Sci U S A., 115(17):4308-4310



Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar I, Gupta RK, Horton JD, Hill JA, Scherer PE. 2018.

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Molecular Metabolism, 11:1-17



Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE. 2018.

Intracellular lipid metabolism impairs β-cell compensation during diet-induced obesity

  1. Clin. Inv., 128(3):1178-1189



Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. 2018.

PPARγ and its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Mol. Cell Biol., 30;38(10)



Zhu Y, Kruglikov IL, Akgul Y, Scherer PE. 2018.

Hyaluronan in Adipogenesis, Adipose Tissue Physiology and Systemic Metabolism

Matrix Biology, 78-79:284-291



Zhang Z, Scherer PE. 2018.

The dysfunctional adipocyte — a cancer cell’s best friend

Nat Rev Endocrinol., 14(3):132-134



Zhu Q, Scherer PE. 2018.

Immunologic and endocrine functions of adipose tissue: implications for kidney disease.

Nat Rev Nephrol., 14(2):105-120



Zhang F, Hao G, Shao M, Hassan G, An YA, Wang Q, Zhu Y, Kusminski CM, Nham K, Gupta RK, Zhai Q, Sun X, Scherer PE*, Oz OK*. 2018.

An Adipose Tissue Atlas: An Image Guided Identification of Human-like BAT and Beige Depots in Rodents.

Cell Metabolism, 27(1):252-262.



Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE. 2018.

Acute Loss of Adipose Tissue-Derived Adiponectin Triggers Immediate Metabolic Deterioration.

Diabetologia, 61(4):932-941




Collaborative Papers and Reviews 2018-2019:


Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Liu Y, Zhu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. 2019.

  1. Clin Inv., in press



Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights

Frankl J , Sherwood A, Clegg DJ, Scherer PE, Öz OK. 2019.

Int J Mol Sci., 5;20(21)



Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW. 2019.

Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.

Kidney Int., in press



Caron A, Reynolds RP, Castorena CM, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK. 2019.

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.

Mol Metab., 27:11-21


Reprint: https://doi.org/10.1016/j.molmet.2019.06.019


Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV.

Spliced X-Box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.

Circulation, 140(7):566-579



Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O’Neal WK, Boucher RC. 2019.

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia.

Am J Respir Crit Care Med., 200(2):220-234



Furman JL, Soyombo A, Czysz AH, Jha MK, Carmody TJ, Mason BL, Scherer PE, Trivedi MH. 2019.

Adiponectin Moderates Antidepressant Treatment Outcome in the Combining Medications to Enhance Depression Outcomes Randomized Clinical Trial.

Pers Med Psychiatry, Aug-Sep; 9-10: 1–7



Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Stern JH, Campbell JE, Scherer PE, Drucker DJ. 2019.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Mol. Metab., 22: 37–48



Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Chakraborty A, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. 2019.

VEGF-D overexpression and lymphatic expansion in murine adipose tissue improves metabolism in obesity.

Am J Pathol., 189(4):924-939



Peri-Okonny P, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, CastorenaCM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W. 2019.

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Circulation, 139(11):1422-1434



Stern JH, Arriaga Y, Gupta A, Verma U, Karri S, Syed S, Khosama L, Mansour J, Meyer J, Scherer PE, Beg MS. 2019.

Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Pancreas, 48(1):e1-e3



Sun F, You J, Lei Y, Sun L, Garza J, Zhang D, Guo M, Scherer PE, Lodge D, Lu XY. 2019.

Adiponectin, via AdipoR1, modulates ventral tegmental area dopamine neuronal activity and anxiety-related behavior.

Mol. Psychiatry, 24(1): 126–144.



Lee C, Kim M, Lee JH, Oh J, Shin HH, Lee SM, Scherer PE, Kwon HM, Choi JH, Park J. 2018.

COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.

J Pathol., 247(1):99-109



Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK. 2018.

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Mol Metab., 14:121-129



Neeland IJ, Singh S, McGuire DK, Vega GL, Roddy T, Reilly DF, Castro-Perez J, Kozlitina J, Scherer PE. 2018.

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.

Diabetologia, 61(12):2570-2579



Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin Y, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. 2018.

HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.

JCI Insight, 3(15):e120159



Cruz VH, Arner EN, Wynne KW, Scherer PE, Brekken RA. 2018.

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.

Mol Metab., 16:139-149



Akgul Y, Constantine R, Bartels M, Scherer P, Davis K, Kenkel JM. 2018.

Utility of Adipocyte Fractions in Fat Grafting in an Athymic Rat Model.

Aesthet Surg J., 38(12):1363-1373



Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH. 2018.

Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.

Mol Metab., 11:212-217



Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M. 2018.

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress and inflammation in non-alcoholic steatohepatitis.

Diabetes Care, 41(6):1235-1243



Wang X, Bi X, Zhang G, Deng Y, Luo X, Xu L, Scherer PE, Ferdous A, Fu G, Gillette TG, Lee AS, Jiang X, Wang ZV. 2018.

Cell Death Differ., 25(12):2181-2194



Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. 2018.

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis.

Nat Med., 24(5):617-627