2019/2020 Publications               

 

Primary Papers, Reviews and Commentaries from the Lab in 2019-2020:

 

Kruglikov IL, Joffin N and PE Scherer. 2020.

The MMP-14/Caveolin Axis and Its Potential Relevance for Lipedema

Nat Rev Endocrinol., in press

 

Zhu Q, An YA, Kim M, Zhang Z, Zhao S, Zhu Y, Wernstedt Asterholm I, Kusminski CM, and PE Scherer. 2020.

Suppressing Adipocyte Inflammation Promotes Insulin Resistance in Mice

Mol Metabolism, in press

http://pubmed.ncbi.nlm.nih.gov/32408016

 

Kruglikov IL, and PE Scherer. 2020.

The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections.

Obesity, in press

http://www.ncbi.nlm.nih.gov/pubmed/32339391

 

Zhao S, Li N, Zhu Y, Straub L, Zhang Z, Wang MY, Qingzhang Zhu Q, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Mol Metabolism, in press

http://www.ncbi.nlm.nih.gov/pubmed/32289482

https://doi.org/10.1016/j.molmet.2020.100995

 

Zhao S, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Leptin: Less is More

Diabetes, 69:823–829

http://www.ncbi.nlm.nih.gov/pubmed/32312898

 

Voices: The Future of Metabolism. 2020.

Cell Metabolism, 31, 1, 3-5

http://www.sciencedirect.com/science/article/pii/S155041311930676X?via%3Dihub

 

An A, Crewe C, Wernstedt Asterholm I, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, and PE Scherer. 2019.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Nat Metabolism, VOL 1 , 1243–1257

http://rdcu.be/bYXYF

http://www.ncbi.nlm.nih.gov/pubmed/31984308

 

Kruglikov IL, and PE Scherer. 2020.

Caveolin as a Universal Target in Dermatology

Int J Mol Sci, 20;21(1)

http://www.ncbi.nlm.nih.gov/pubmed/31877626

http://www.mdpi.com/1422-0067/21/1/80/pdf

 

Kusminski CM, Ghaben AL, Morley TS, Samms RJ, Adams AC, An Y, Johnson JA,

Joffin N, Onodera T, Crewe C, Holland WL, Gordillo R and PE Scherer. 2020.

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-cell Hyperplasia

Diabetes, 69(3):313-330

http://www.ncbi.nlm.nih.gov/pubmed/31882562

 

Kruglikov IL and PE Scherer. 2019

Caveolin-1 as a possible target in treatment for acne.

Exp Dermatol. 29(2):177-183

http://www.ncbi.nlm.nih.gov/pubmed/31769542

 

PE Scherer. 2019.

Mechanisms Underlying the Metabolic Syndrome

Series edited by Philipp E. Scherer

  1. Clin Inv., 129(10)

http://www.jci.org/review_series/107

 

Wang QA and PE Scherer. 2019.

Remodeling of Murine Mammary Adipose Tissue during Pregnancy, Lactation, and Involution

Journal of Mammary Gland Biology and Neoplasia, 24(3):207-212.

http://www.ncbi.nlm.nih.gov/pubmed/31512027

 

Kruglikov IL, Zhang Z and PE Scherer. 2019.

Caveolin-1 in Skin Aging: From Innocent Bystander to Major Contributor

Ageing Research Reviews, 55:100959

http://doi.org/10.1016/j.arr.2019.100959

 

Shao M, Wang QA, Song A, Vishvanath L, Busbuso NC, Scherer PE*, Gupta RK*. 2019.  *co-corresponding authors

Cellular Origins of Beige Fat Cells Revisited.

Diabetes. 2019 Oct;68(10):1874-1885

http://www.ncbi.nlm.nih.gov/pubmed/31540940

 

Zhang Z, Shao M, Hepler C, Zi Z, Zhao S, An A, Zhu Yi, Ghaben A, Wang M-Y, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK and PE Scherer. 2019.

Dermal adipose tissue has high plasticity and undergoes reversible de-differentiation in mice.

  1. Clin Inv., 129(12):5327-5342

http://www.ncbi.nlm.nih.gov/pubmed/31503545

 

Stern JH, Smith GI, Chen S, Unger RH, Klein S and PE Scherer. 2019.

Obesity dysregulates fasting-induced changes in glucagon secretion

J Endocrinol., 243(2):149-160

http://dx.doi.org/10.1530/JOE-19-0201

Reprint: http://www.ncbi.nlm.nih.gov/pubmed/31454790

 

Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GW, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z and PE Scherer. 2019.

Partial Leptin Reduction as an Effective Weight Loss Strategy

Cell Metabolism, 30; (4)706-719

http://www.ncbi.nlm.nih.gov/pubmed/31495688

https://authors.elsevier.com/a/1Zq6d5WXUlEpAQ

 

Kusminski CM and PE Scherer. 2019.

Lowering ceramides to overcome diabetes

Science, 365(6451):319-320.

http://www.ncbi.nlm.nih.gov/pubmed/31346052

Reprint: http://science.sciencemag.org/cgi/rapidpdf/365/6451/319?ijkey=7iHpher3qVBIg&keytype=ref&siteid=sci

 

Crewe C, Zhu Y, Paschoal VA, Joffin N, Ghaben AL, Gordillo R, Oh DY, Liang G, Horton JD and PE Scherer. 2019.

SREBP-regulated Adipocyte Lipogenesis is Dependent on Substrate Availability and Redox Modulation of mTORC1

JCI Insight, 5. pii: 129397. doi: 10.1172/jci.insight.129397

http://www.ncbi.nlm.nih.gov/pubmed/31310592

 

Funcke JB and PE Scherer. 2019

Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

  1. Lipid Res., 60(10):1648-1684

http://www.jlr.org/content/early/2019/06/17/jlr.R094060.full.pdf+html

 

Gliniak CM and PE Scherer. 2019

Critical lipids link breastfeeding to healthy adipose tissue in infancy and adulthood 

J Clin Inv., 130:2198-2200

http://www.ncbi.nlm.nih.gov/pubmed/31081800

 

Kruglikov IL and PE Scherer. 2019.

Caveolin-1 as a target in prevention and treatment of hypertrophic scarring

npj Aging and Mechanisms of Disease, 4:9 doi: 10.1038/s41536-019-0071-x

http://rdcu.be/byHdt

http://www.ncbi.nlm.nih.gov/pubmed/31044089

 

Bu D, Crewe C, Kusminski CM, Gordillo R, Ghaben AL, Kim M, Park J, Deng H, Xiong W, Liu X-Z, Lønning PE, Halberg N, Rios A, Chang Y, Gonzalez A, Zhang N, An Z and PE Scherer. 2019.

Human Endotrophin as a Driver of Malignant Tumor Growth

JCI Insight, ;4(9):e125094

http://www.ncbi.nlm.nih.gov/pubmed/30896449

 

Straub LG and PE Scherer. 2019.

Metabolic Messengers: Adiponectin

Nature Metabolism, 1, 334–339

http://rdcu.be/bq3NN

 

Ye R, Onodera T and PE Scherer. 2019.

Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes

J Endocr Soc., 3(3):617-631

http://www.ncbi.nlm.nih.gov/pubmed/30834357

 

Ye R, Onodera T, Blanchard P-G, Kusminski CM, Esser V, Brekken RA and PE Scherer. 2019.

β1 syntrophin supports autophagy initiation and protects against cerulein-induced acute pancreatitis.

Am J Pathol., 189(4):813-825

http://www.ncbi.nlm.nih.gov/pubmed/30653956

 

Kruglikov IL and PE Scherer. 2019.

Caveolin-1 as a Pathophysiological Factor and Target in Psoriasis

npj Aging and Mechanisms of Disease, 5:4. doi: 10.1038/s41514-019-0034-x.

https://rdcu.be/bkfWC

http://www.ncbi.nlm.nih.gov/pubmed/31044089

___________________________________________________________________

 

Collaborative Papers and Reviews 2019-2020:

 

Zhao Zhang Z, Thomas Gallagher T, Scherer PE, Beutler B. 2020.

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Proc Natl Acad Sci U S A, in press

http://pubmed.ncbi.nlm.nih.gov/32381739/

 

Pedersen L, Panahandeh P, Siraji MI, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. 2020.

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer.

Cancer Res., in press

http://www.ncbi.nlm.nih.gov/pubmed/32291319

 

Li X, Zhao Y, Chen C, Yang L, Lee HH, Wang Z, Zhang N, Kolonin MG, An Z, Ge X, Scherer PE, Sun K. 2020.

The critical role of MMP14 in adipose tissue remodeling during obesity.

Mol Cell Biol., 30;40(8). pii: e00564-19.

http://www.ncbi.nlm.nih.gov/pubmed/31988105

 

Zaki P, Domingues ELBC, Amjad FM, Narde MB, Gonçalves KR, Viana ML, de Paula H, de Lima WG, Huang H, Bahia MT, Scherer PE, Dos Santos FM, Weiss LM, Tanowitz HB. 2020.

The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection.

Parasitol Res., in press

http://www.ncbi.nlm.nih.gov/pubmed/32206887

 

Williams T, Guerrero-Ros I, Ma Y, Matos Dos Santos F, Scherer PE, Gordillo R, Horta A, Macian F, Weiss LM, Huang H. 2020.

Induction of effective immunity against Trypanosoma cruzi.

Williams T, Guerrero-Ros I, Ma Y, Matos Dos Santos F, Scherer PE, Gordillo R,

Infect Immun., 23;88(4)

http://www.ncbi.nlm.nih.gov/pubmed/31907197

 

Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. 2020.

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.

FASEB J, 34(2):2087-2104

http://www.ncbi.nlm.nih.gov/pubmed/31907991

 

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Liu Y, Zhu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. 2020.

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

  1. Clin Inv., 130(1):247-257.

http://www.ncbi.nlm.nih.gov/pubmed/31573981

 

Frankl J , Sherwood A, Clegg DJ, Scherer PE, Öz OK. 2019.

Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights

Int J Mol Sci., 5;20(21)

http://www.ncbi.nlm.nih.gov/pubmed/31694216

 

Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW. 2019.

Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.

Kidney Int., 96(6):1359-1373

http://www.ncbi.nlm.nih.gov/pubmed/31601454

 

Caron A, Reynolds RP, Castorena CM, Michael NJ, Lee CE, Lee S, Berdeaux R, Scherer PE, Elmquist JK. 2019.

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.

Mol Metab., 27:11-21

http://www.ncbi.nlm.nih.gov/pubmed/31279640

Reprint: https://doi.org/10.1016/j.molmet.2019.06.019

 

Wang X, Deng Y, Zhang G, Li C, Ding G, May HI, Tran DH, Luo X, Jiang DS, Li DL, Wei X, Xu L, Ferdous A, Gillette TG, Scherer PE, Jiang X, Wang ZV. 2019.

Spliced X-Box Binding Protein 1 Stimulates Adaptive Growth Through Activation of mTOR.

Circulation, 140(7):566-579

https://www.ncbi.nlm.nih.gov/pubmed/31177839

 

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O’Neal WK, Boucher RC. 2019.

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in IPF Airway Epithelia.

Am J Respir Crit Care Med., 200(2):220-234

http://www.ncbi.nlm.nih.gov/pubmed/30973754

 

Furman JL, Soyombo A, Czysz AH, Jha MK, Carmody TJ, Mason BL, Scherer PE, Trivedi MH. 2019.

Adiponectin Moderates Antidepressant Treatment Outcome in the Combining Medications to Enhance Depression Outcomes Randomized Clinical Trial.

Pers Med Psychiatry, Aug-Sep; 9-10: 1–7

http://www.ncbi.nlm.nih.gov/pubmed/30859144

 

Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Stern JH, Campbell JE, Scherer PE, Drucker DJ. 2019.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Mol. Metab., 22: 37–48

http://www.ncbi.nlm.nih.gov/pubmed/30772257

 

Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Chakraborty A, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. 2019.

VEGF-D overexpression and lymphatic expansion in murine adipose tissue improves metabolism in obesity.

Am J Pathol., 189(4):924-939

http://www.ncbi.nlm.nih.gov/pubmed/30878136

 

Peri-Okonny P, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, CastorenaCM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W. 2019.

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Circulation, 139(11):1422-1434

http://www.ncbi.nlm.nih.gov/pubmed/30612451

 

Stern JH, Arriaga Y, Gupta A, Verma U, Karri S, Syed S, Khosama L, Mansour J, Meyer J, Scherer PE, Beg MS. 2019.

Fasting and Glucose-Stimulated Changes in Plasma Glucagon in Pancreatic Cancer: Potential Biomarkers for Detection?

Pancreas, 48(1):e1-e3

http://www.ncbi.nlm.nih.gov/pubmed/30531245

 

Sun F, You J, Lei Y, Sun L, Garza J, Zhang D, Guo M, Scherer PE, Lodge D, Lu XY. 2019.

Adiponectin, via AdipoR1, modulates ventral tegmental area dopamine neuronal activity and anxiety-related behavior.

Mol. Psychiatry, 24(1): 126–144.

http://www.ncbi.nlm.nih.gov/pubmed/29988086