2020/2021 Publications               

 

Primary Papers, Reviews and Commentaries from the Lab in 2019-2020:

 

Kruglikov IL and Scherer PE. 2021.

Pre-existing and Inducible Endotoxemia as Crucial Contributors to Severity of COVID-19 Outcomes.

PLoS Pathog., in press

 

Hagström H, Bu D, Nasr P, Ekstedt M, Hegmar H, Kechagias S, Zhang N, An Z, Stål P, Scherer PE. 2021.

Serum Levels of Endotrophin are Associated with Nonalcoholic Steatohepatitis

Scand J Gastroenterol., in press

https://pubmed.ncbi.nlm.nih.gov/33556256/

 

Crewe C, Scherer PE. 2021.

Intercellular and interorgan crosstalk through adipocyte extracellular vesicles

Rev Endocr Metab Disord., in press

https://link.springer.com/article/10.1007/s11154-020-09625-x

https://pubmed.ncbi.nlm.nih.gov/33447986/

 

Zhao S, Kusminski CM and Scherer PE. 2021.

Adiponectin, Leptin and Cardiovascular Disorders

Circ Res., 128(1):136-149

http://pubmed.ncbi.nlm.nih.gov/33411633/

 

Joffin N, Paschoal VA, Gliniak CM, Crewe C, Elnwasany A, Szweda LI, Zhang Q, Hepler C, Kusminski CM, Gordillo R, Oh DY, Gupta RK, Scherer PE. 2021.

Mitochondrial metabolism as a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.              

Cell Stem Cell, in press

https://pubmed.ncbi.nlm.nih.gov/33539722/

 

Scherer PE, Newgard CB. 2020.

A tribute to Roger H. Unger (1924-2020).

J Clin Invest. 130(12):6191-6193.

http://pubmed.ncbi.nlm.nih.gov/33258805/

 

Field BC, Gordillo R, Scherer PE. 2020.

The Role of Ceramides in Diabetes and Cardiovascular Disease

Regulation of Ceramides by Adipokines

Front Endocrinol, 11:569250

http://pubmed.ncbi.nlm.nih.gov/33133017/

 

Kim M, Lee C, Seo DY, Horton JD, Park JY, Scherer PE. 2020.

The Impact of Endotrophin on the Progression of Chronic Liver Disease

Experimental & Molecular Medicine, 52(10):1766-1776

http://pubmed.ncbi.nlm.nih.gov/33110211/

 

Kruglikov IL, Shah M, Scherer PE. 2020.

Obesity and diabetes as comorbidities for COVID-19:

Underlying Mechanisms and the Role of Viral-Bacterial Interactions.

Elife, 9:e61330

http://pubmed.ncbi.nlm.nih.gov/32930095/

 

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts

Zhang Z, Kruglikov IL, Zhao S, Zi Z, Gliniak CM, Li N, Wang MY, Zhu Q, Kusminski CM, Scherer PE. 2020.

Exp Dermatol, 30(1):102-111

http://pubmed.ncbi.nlm.nih.gov/32866299/

 

Gliniak CM, PE Scherer. 2020.

PHOSPHO1 puts the breaks on thermogenesis in brown adipocytes.

Proc Natl Acad Sci USA., 117(29):16726-16728.

http://pubmed.ncbi.nlm.nih.gov/32641502/

 

Kruglikov IL, Joffin N, PE Scherer. 2020.

The MMP-14/Caveolin Axis and Its Potential Relevance for Lipedema

Nat Rev Endocrinol., 16(11):669-674.

http://pubmed.ncbi.nlm.nih.gov/32792644/

 

Zhu Q, An YA, Kim M, Zhang Z, Zhao S, Zhu Y, Wernstedt Asterholm I, Kusminski CM, and PE Scherer. 2020.

Suppressing Adipocyte Inflammation Promotes Insulin Resistance in Mice

Mol Metabolism, 39:101010

https://doi.org/10.1016/j.molmet.2020.101010

http://pubmed.ncbi.nlm.nih.gov/32408016

 

Kruglikov IL, and PE Scherer. 2020.

The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections.

Obesity, 28(7):1187-1190

http://www.ncbi.nlm.nih.gov/pubmed/32339391

 

Zhao S, Li N, Zhu Y, Straub L, Zhang Z, Wang MY, Qingzhang Zhu Q, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Partial leptin deficiency confers resistance to diet-induced obesity in mice

Mol Metabolism, in press

http://www.ncbi.nlm.nih.gov/pubmed/32289482

https://doi.org/10.1016/j.molmet.2020.100995

 

Zhao S, Kusminski CM, Elmquist JK, and PE Scherer. 2020.

Leptin: Less is More

Diabetes, 69:823–829

http://www.ncbi.nlm.nih.gov/pubmed/32312898

 

Voices: The Future of Metabolism. 2020.

Cell Metabolism, 31, 1, 3-5

http://www.sciencedirect.com/science/article/pii/S155041311930676X?via%3Dihub

 

An A, Crewe C, Wernstedt Asterholm I, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, and PE Scherer. 2019.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity

Nat Metabolism, VOL 1 , 1243–1257

http://rdcu.be/bYXYF

http://www.ncbi.nlm.nih.gov/pubmed/31984308

 

Kruglikov IL, and PE Scherer. 2020.

Caveolin as a Universal Target in Dermatology

Int J Mol Sci, 20;21(1)

http://www.ncbi.nlm.nih.gov/pubmed/31877626

http://www.mdpi.com/1422-0067/21/1/80/pdf

 

Kusminski CM, Ghaben AL, Morley TS, Samms RJ, Adams AC, An Y, Johnson JA,

Joffin N, Onodera T, Crewe C, Holland WL, Gordillo R and PE Scherer. 2020.

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-cell Hyperplasia

Diabetes, 69(3):313-330

http://www.ncbi.nlm.nih.gov/pubmed/31882562

___________________________________________________________________

 

Collaborative Papers and Reviews 2020-2021:

 

Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G and RJ Davis. 2021.

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21.

Genes Dev., 35(1-2):133-146

http://pubmed.ncbi.nlm.nih.gov/33334822/

 

Apostolopoulou M, Gordillo R, Gancheva S, Strassburger K, Herder C, Esposito I, Schlensak M, Scherer PE, Roden M. 2020.

Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans.

BMJ Open Diabetes Res Care.;8(2):e001860 http://pubmed.ncbi.nlm.nih.gov/33219119/

 

Zhang Z, Gallagher T, Scherer PE, Beutler B. 2020.

Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Proc Natl Acad Sci U S A, 117(21):11829-11835.

http://pubmed.ncbi.nlm.nih.gov/32381739/

 

Pedersen L, Panahandeh P, Siraji MI, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. 2020.

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer.

Cancer Res., 80(11):2163-2174

http://www.ncbi.nlm.nih.gov/pubmed/32291319

 

Li X, Zhao Y, Chen C, Yang L, Lee HH, Wang Z, Zhang N, Kolonin MG, An Z, Ge X, Scherer PE, Sun K. 2020.

The critical role of MMP14 in adipose tissue remodeling during obesity.

Mol Cell Biol., 30;40(8). pii: e00564-19.

http://www.ncbi.nlm.nih.gov/pubmed/31988105

 

Zaki P, Domingues ELBC, Amjad FM, Narde MB, Gonçalves KR, Viana ML, de Paula H, de Lima WG, Huang H, Bahia MT, Scherer PE, Dos Santos FM, Weiss LM, Tanowitz HB. 2020.

The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection.

Parasitol Res., 119(6):1845

http://www.ncbi.nlm.nih.gov/pubmed/32206887

 

Williams T, Guerrero-Ros I, Ma Y, Matos Dos Santos F, Scherer PE, Gordillo R, Horta A, Macian F, Weiss LM, Huang H. 2020.

Induction of effective immunity against Trypanosoma cruzi.

Williams T, Guerrero-Ros I, Ma Y, Matos Dos Santos F, Scherer PE, Gordillo R,

Infect Immun., 23;88(4)

http://www.ncbi.nlm.nih.gov/pubmed/31907197

 

Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. 2020.

Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress.

FASEB J, 34(2):2087-2104

http://www.ncbi.nlm.nih.gov/pubmed/31907991

 

Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Liu Y, Zhu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA. 2020.

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.

  1. Clin Inv., 130(1):247-257.

http://www.ncbi.nlm.nih.gov/pubmed/31573981